In vitro release studies of methylmethacrylate liberation from acrylic cement powder
In vitro release studies of methylmethacrylate liberation from acrylic cement powder
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DOI：
10.1016/s0378-5173(99)00468-8
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发表时间：
2000-03-20
影响因子：
5.8
通讯作者：
Castro, M
中科院分区：
文献类型：
--
作者：
Bettencourt, A;Calado, A;Castro, M
骨水泥或聚甲基丙烯酸甲酯（PMMA）通常用于骨锚定骨水泥假体。暴露于PMMA粉末的培养基的细胞毒性作用可能与丙烯酸水泥应用相关的长期问题有关，因为单体（甲基丙烯酸甲酯）是水泥成分之一，部分负责细胞毒性作用。本文报道了不同实验条件下丙烯酸骨水泥粉单体释放的研究：PMMA的凝固时间（溶液和空气）和不同的培养基组成。采用高效液相色谱法测定残留单体。用数学模型对实验溶出数据进行了分析，结果表明单体释放受研究变量的影响较小。单体释放似乎是一种表面现象，表明单体的可能作用主要是由于未聚合单体的初始损失，而不是由于已聚合水泥的进一步解聚。(C) 2000 Elsevier Science B.V.版权所有
Bone cement or polymethylmethacrylate (PMMA) is commonly used for anchoring cemented prosthesis to the bone. Cytotoxic effect of culture media exposed to PMMA powder may be related with long term problems associated with acrylic cement application, being the monomer (methylmethacrylate) one of the cement's component partly responsible for the cytotoxic effect. The present work reports the studies of monomer release from acrylic bone cement powder under different experimental conditions: setting time of PMMA (in solution and air) and different culture media composition. High-performance liquid chromatography was used for the determination of residual monomer. Mathematical models were applied to experimental dissolution data revealing that monomer release is lightly affected by the studied variables. The monomer release seems to be a surface phenomena, suggesting that the possible actions of monomer will mainly be due to the initial loss of non polymerized monomer rather than to further depolymerization of the already polymerized cement. (C) 2000 Elsevier Science B.V. All rights reserved.