Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient
Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient
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DOI：
10.1053/gast.2001.21907
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发表时间：
2001-02-01
期刊：
影响因子：
29.4
通讯作者：
Laine, L
中科院分区：
文献类型：
--
作者：
Laine, L
非甾体类抗炎药（NSAIDs）可能是当今美国胃十二指肠损伤的最常见原因，定期服用NSAIDs的患者中约有一半有胃糜烂，15%-30%在内镜检查时有溃疡。然而，NSAID引起的临床胃肠道（GI）事件的发生率要低得多。3%-4.5%服用NSAID的患者可能发生临床上消化道事件，约1.5%发生严重并发症事件。然而，风险与临床特征（如溃疡或GI事件史、年龄、伴随抗凝剂或类固醇使用和NSAID剂量）的关系差异很大。本综述讨论了NSAID使用者临床胃肠道疾病的风险，风险增加的预测因素，以及预防NSAID相关胃肠道疾病的策略。
Nonsteroidal anti-inflammatory drugs (NSAIDs) are probably the most common cause of gastroduodenal injury in the United States today, Approximately half of patients who regularly take NSAIDs have gastric erosions, and 15%-30% have ulcers when they are examined endoscopically. However, the incidence of clinical gastrointestinal (GI) events caused by NSAIDs is much lower. Clinical upper GI events may occur in 3%-4.5% of patients taking NSAIDs, and serious complicated events develop in approximately 1.5%. However, the risk varies widely in relationship to clinical features such as history of ulcers or GI events, age, concomitant anticoagulant or steroid use, and NSAID dose. This review discusses the risks of clinical GI disease in NSAID users, the predictors of increased risk, and strategies for prevention of NSAID-associated GI disease.