Effect of granulocyte colony-stimulating factor on the course of infection with gram-positive bacteria in mice during granulocytopenia induced by sublethal irradiation or cyclophosphamide
Effect of granulocyte colony-stimulating factor on the course of infection with gram-positive bacteria in mice during granulocytopenia induced by sublethal irradiation or cyclophosphamide
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DOI：
10.1093/infdis/174.2.417
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发表时间：
1996-08-01
影响因子：
6.4
通讯作者：
vanFurth, R
中科院分区：
文献类型：
--
作者：
Buisman, AM;Langermans, JAM;vanFurth, R
本研究评估了粒细胞集落刺激因子（G-CSF）对亚致死全身照射或环磷酰胺治疗引起的白细胞减少小鼠感染单核细胞增生李斯特菌或金黄色葡萄球菌的影响。在感染过程中，我们评估了大腿肌、脾脏和肝脏中粒细胞的作用。G-CSF处理使幼稚小鼠血液中粒细胞数量增加；感染后，这些数字进一步增加，但G-CSF不影响组织中细菌的生长。环磷酰胺治疗和亚致死照射均可减少血细胞数量，而G-CSF治疗对血细胞数量无影响。然而，在环磷酰胺处理的小鼠感染期间，G-CSF增加了循环和感染部位的粒细胞数量，减少了组织中的细菌数量。用G-CSF治疗不影响辐照小鼠的粒细胞数量或感染过程。
This study assesses the effect of granulocyte colony-stimulating factor (G-CSF) on the outcome of infection with Listeria monocytogenes or Staphylococcus aureus in mice during leukocytopenia induced by sublethal total body irradiation or cyclophosphamide treatment. The role of granulocytes during infection was assessed in the thigh muscle, spleen, and liver. G-CSF treatment in naive mice increased the number of blood granulocytes; upon infection, these numbers increased further, but G-CSF did not affect the outgrowth of bacteria in the tissues. Cyclophosphamide treatment and sublethal irradiation decreased the number of blood granulocytes, which was not affected by G-CSF treatment. However, during infection in cyclophosphamide-treated mice, G-CSF increased the number of granulocytes in the circulation and at the site of infection and decreased the number of bacteria in the tissues. Treatment with G-CSF did not affect the number of granulocytes or the course of infection in irradiated mice.