Glutathione peroxidase‐like activity of caeruloplasmin as an important lung antioxidant
Glutathione peroxidase‐like activity of caeruloplasmin as an important lung antioxidant
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DOI：
10.1016/s0014-5793(99)01142-4
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发表时间：
1999-09
期刊：
影响因子：
3.5
通讯作者：
Yong Seek Park;Kenji Suzuki;Naoyuki Taniguchi;John M.C. Gutteridge
中科院分区：
文献类型：
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作者：
Yong Seek Park;Kenji Suzuki;Naoyuki Taniguchi;John M.C. Gutteridge
含铜血浆蛋白铜蓝蛋白（Cp）已被证明具有几种氧化酶活性，但其亚铁离子氧化（铁氧化酶）活性除外，迄今为止似乎没有什么生物学相关性。最近，Kim和他的同事（Kim et al. (1998) FEBS Lett. 431, pp. 473-475）观察到Cp可以在硫醇存在的情况下催化去除过氧化氢。在这里，我们表明，Cp可以去除过氧化氢和脂质氢过氧化物，在生理相关浓度的还原性谷胱甘肽已知存在于肺和肺内膜液中。Cp的谷胱甘肽过氧化物酶样活性及其氧化铁酶活性将完全去除芬顿化学和脂质过氧化所需的主要反应物。
The copper-containing plasma protein caeruloplasmin (Cp) has been shown to possess several oxidase activities, but with the exception of its ferrous ion oxidising (ferroxidase) activity which so far appear to be of minor biological relevance. Recently, Kim and colleagues (Kim et al. (1998) FEBS Lett. 431, pp. 473–475) observed that Cp can catalytically remove hydrogen peroxide in the presence of thiols. Here, we show that Cp can remove both hydrogen peroxide and lipid hydroperoxides at physiologically relevant concentrations of reduced glutathione known to be present in lung and lung lining fluid. The glutathione peroxidase-like activity of Cp together with its ferroxidase activity would completely remove the primary reactants required for both Fenton chemistry and lipid peroxidation.