Comparative Effects of Losartan, Captopril, and Enalapril on Murine Acute Myocarditis Due to Encephalomyocarditis Virus
Comparative Effects of Losartan, Captopril, and Enalapril on Murine Acute Myocarditis Due to Encephalomyocarditis Virus
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氯沙坦、卡托普利和依那普利对脑心肌炎病毒引起的小鼠急性心肌炎的比较作用
DOI：
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发表时间：
1995
影响因子：
3
通讯作者：
I. Kobayashi
中科院分区：
文献类型：
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作者：
M. Araki;T. Kanda;S. Imai;Tadashi Suzuki;K. Murata;I. Kobayashi
总结：氯沙坦是一种新近开发的非肽类血管紧张素II（AII）受体拮抗剂，从脑心肌炎病毒接种后第7天开始，口服给药病毒性心肌炎小鼠14天。血管紧张素转换酶抑制剂（ACEI）Captopril和依那普利也以同样的方式给药，以比较这三种药物对心肌炎、急性心力衰竭和左心室（LV）肥大程度的治疗效果。氯沙坦（60 mg/kg/天）和卡托普利（7.5 mg/ kg/天）可降低心脏重量和心脏重量/体重比，但依那普利（1 mg/kg/天）不降低。氯沙坦组和卡托普利组左室壁厚度和腔径均减小。开搏通减少心肌坏死和炎症，而依那普利减少心肌坏死，但不减少炎症。然而，研究的氯沙坦剂量（1.2、12、60 mg/ kg/天）均未影响病毒感染引起的心肌坏死和炎症。因此，特异性阻断AII对充血性心力衰竭（CHF）和LV肥大有益，但对病毒诱发的炎症和损伤无效。
Summary: Losartan, a recently developed nonpeptide angiotensin II (AII) receptor antagonist, was orally administered for 14 days to mice with viral myocarditis, beginning 7 days after encephalomyocarditis virus inoculation. The angiotensin-converting enzyme inhibitors (ACEI) captopril and enalapril were also administered in the same manner to compare the therapeutic effects of these three drugs on the degree of myocarditis, acute heart failure, and left ventricular (LV) hypertrophy. Heart weight and the heart weight/body weight ratio were reduced by losartan (60 mg/kg/day) and captopril (7.5 mg/ kg/day), but not by enalapril (1 mg/kg/day). LV wall thickness and cavity dimension were decreased in the losartan and captopril groups. Captopril reduced both myocardial necrosis and inflammation, whereas enalapril reduced myocardial necrosis but not inflammation. However, none of the studied losartan doses (1.2, 12, 60 mg/ kg/day) influenced myocardial necrosis and inflammation resulting from viral infection. Thus, specific blockade of AII is beneficial in congestive heart failure (CHF) and LV hypertrophy but is not effective in viral-evoked inflammation and injury.