Cognitive effects of nicotine in humans: an fMRI study
Cognitive effects of nicotine in humans: an fMRI study
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DOI：
10.1016/s1053-8119(03)00110-1
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发表时间：
2003-07-01
期刊：
影响因子：
5.7
通讯作者：
Sharma, T
中科院分区：
文献类型：
--
作者：
Kumari, V;Gray, JA;Sharma, T
为了阐明尼古丁认知效应的神经相关性，我们研究了行为表现和血氧水平依赖性区域脑活动，使用功能性磁共振成像，在一个参数的“n-back”任务后，在健康的非吸烟男性尼古丁（12微克/公斤体重）或生理盐水管理。与安慰剂相比，尼古丁改善了所有活动条件下的准确性（P = 0.008）（2%-11%），并对潜伏期有负荷特异性影响（P = 0.004;在最高记忆负荷时减少43.78%）。在任务激活的顶叶和额叶区域网络内（P < 0.05，在体素水平上校正），尼古丁在前扣带回、上级额叶皮层和上级顶叶皮层中产生了增加的反应（P < 0.05;在感兴趣区域内未校正）。在所有活动条件下，中脑顶盖以及休息时海马旁回、小脑和内侧枕叶的反应也增加（P = 0.05;未校正）。目前的观察点改变神经元活动的分布式神经网络与在线任务监测和注意力和唤醒系统作为潜在的尼古丁相关的增强人类受试者的注意力和工作记忆。(C)2003 Elsevier Science（美国）。All rights reserved.
To elucidate the neural correlates of cognitive effects of nicotine, we examined behavioral performance and blood oxygenation level-dependent regional brain activity, using functional magnetic resonance imaging, during a parametric "n-back" task in healthy nonsmoking males after the administration of nicotine (12 mug/kg body weight) or saline. Nicotine, compared to placebo, improved accuracy (P = 0.008) in all active conditions (2%-11%), and had a load-specific effect on latency (P = 0.004; 43.78% decrease at the highest memory load). Within a network of parietal and frontal areas activated by the task (P < 0.05, corrected at the voxel level), nicotine produced an increased response (P < 0.05; uncorrected within the regions of interest) in the anterior cingulate, superior frontal cortex, and superior parietal cortex. It also produced an increased response in the midbrain tectum in all active conditions and in the parahippocampal gyrus, cerebellum, and medial occipital lobe during rest (P = 0.05; uncorrected). The present observations point to altered neuronal activity in a distributed neural network associated with on-line task monitoring and attention and arousal systems as underlying nicotine-related enhancement of attention and working memory in human subjects. (C) 2003 Elsevier Science (USA). All rights reserved.