HWA: Hypoferritinemia without anemia a hidden hematology disorder.
HWA: Hypoferritinemia without anemia a hidden hematology disorder.
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DOI：
10.4103/2249-4863.214986
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发表时间：
2017-01-01
影响因子：
1.4
通讯作者：
Al-Jafar, Hassan A
中科院分区：
文献类型：
--
作者：
Al-Jafar, Hassan A
简介：贫血是一种红细胞（RBC）和血红蛋白（Hb）数量不足以满足身体生理需求的疾病。无贫血性低铁蛋白血症（HWA）可导致全身无力、易疲劳、抑郁、脱发等临床表现，但全血细胞计数（CBC）正常。HWA与缺铁性贫血（IDA）不同，因为RBC，Hb或CBC的任何其他参数都没有减少。在HWA，低铁蛋白血症可能会被错过，因为血清铁蛋白并不总是要求由全科医生。材料和方法：回顾性研究6993例低铁蛋白血症患者从我们的计算机数据库2010年至2016年。检测HWA的指标包括血清铁蛋白、红细胞、血红蛋白、红细胞压积、平均红细胞体积和平均红细胞血红蛋白（0.018%）低铁蛋白血症患者，男女比例为1.7-1。结论：HWA是一种被掩盖的血液学疾病，需要新的命名法将其与IDA区分开来，因为它们是两种不同的疾病，尽管两者都是血清铁蛋白低。HWA不是一种潜在的IDA，因为它可能发生在那些不会像反复静脉切除术的红细胞增多症患者那样出现贫血的患者中。
INTRODUCTION: Anemia is a condition, in which the number of red blood cells (RBC) and the hemoglobin (Hb) is insufficient to meet the body's physiologic needs. Hypoferritinemia without anemia (HWA) could cause masked clinical manifestations as general weakness, easy fatigability, depressed mode, and hair loss but with normal complete blood count (CBC) parameters. HWA is deferent from iron deficiency anemia (IDA) because there is no reduction in the RBC, Hb, or any of the other parameters of the CBC. In HWA, the hypoferritinemia could be missed because serum ferritin not always requested by general practitioners.MATERIALS AND METHODS: A retrospective study conducted on 6993 patients of hypoferritinemia patients from our computerized database from 2010 to 2016. The parameters investigated to detect HWA disorder were serum ferritin, RBC, Hb, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin.RESULTS: HWA is found in 130 (0.018%) hypoferritinemia patients, in a ratio 1.7-1 females to male.CONCLUSION: HWA is a masked hematology disorder which needs new nomenclature to distinguish it from IDA because they are two deferent disorders although both of them have low serum ferritin. HWA is not a latent IDA because it could happen in patients whom will not get anemia as in polycythemia patients on recurrent veinesection treatement.