MEASUREMENT OF ALCOHOL PREFERENCE IN GENETIC EXPERIMENTS
MEASUREMENT OF ALCOHOL PREFERENCE IN GENETIC EXPERIMENTS
复制标题
DOI：
10.1037/h0043100
复制
发表时间：
1964-01-01
期刊：
影响因子：
--
通讯作者：
FULLER, JL
中科院分区：
文献类型：
--
作者：
FULLER, JL
A/J、C3HeB/J、C57BL/6J和DBA/2J小鼠及其F1杂交种的酒精摄入评分采用一种新方法，该方法涉及同时从6种浓度范围为：5%到16%。这种方法的群体差异与群体手段无关，使该技术适用于遗传研究。菌株间差异极显著。结果表明，4种基因型的特定配合力比一般配合力对酒精摄入量的影响更大。这一发现增加了仅通过观察两个菌株之间的杂交来推断遗传系统影响行为的普遍性的风险。
Alcohol intake scores of A/J, C3HeB/J, C57BL/6J, and DBA/2J mice and their F1 hybrids were determined by a new method involving simultaneous choice from 6 solutions ranging in strength from .5% to 16%. Group variances with this method are independent of group means making the technique suitable for genetic studies. Differences between strains were highly significant. Results on the hybrids indicated that specific combining activity of the 4 genotypes tested was more important than general combining activity in determining alcohol intake. This finding points up the risk of inferring the generality of a genetic system affecting behavior from observations of a cross between only 2 strains.