The Prevention and Treatment of Intestinal Failure-associated Liver Disease in Neonates and Children
The Prevention and Treatment of Intestinal Failure-associated Liver Disease in Neonates and Children
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DOI：
10.1016/j.suc.2011.02.003
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发表时间：
2011-06-01
影响因子：
3.1
通讯作者：
Puder, Mark
中科院分区：
文献类型：
--
作者：
Nehra, Deepika;Fallon, Erica M.;Puder, Mark
肠衰竭相关性肝病（IFALD）是接受长期肠外营养（PN）的儿科患者的常见且可能危及生命的问题。IFALD的危险因素包括早产、低出生体重、长期PN、肠道淤滞和败血症。预防性策略是改善IFALD结局的基石，包括肠内喂养、PN撤机、减少脂肪乳剂剂量以及早期识别和治疗脓毒症。最近的研究也证明了鱼油脂肪乳剂在预防和治疗IFALD方面的疗效。移植是终末期肝病的一种选择，但与显著的发病率和死亡率相关。
Intestinal Failure Associated Liver Disease (IFALD) is a common and potentially life-threatening problem for pediatric patients receiving long-term parenteral nutrition (PN). Risk factors for IFALD include premature birth, low birth weight, long-term PN, intestinal stasis and sepsis. Preventative strategies are the cornerstone of improving outcomes in IFALD and include enteral feeding, weaning of PN, reduced dose lipid emulsions and the early recognition and treatment of sepsis. Recent work also demonstrates the efficacy of fish-oil based lipid emulsions in the prevention and treatment of IFALD. Transplantation is an option for end-stage liver disease but is associated with significant morbidity and mortality.