Evaluation of the wound healing effect of some Jordanian traditional medicinal plants formulated in Pluronic F127 using mice (Mus musculus)
Evaluation of the wound healing effect of some Jordanian traditional medicinal plants formulated in Pluronic F127 using mice (Mus musculus)
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DOI：
10.1016/j.jep.2006.07.010
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发表时间：
2007-01-03
影响因子：
5.4
通讯作者：
Al-Hussaini, Maysa
中科院分区：
文献类型：
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作者：
Khalil, Enam A.;Afifi, Fatma U.;Al-Hussaini, Maysa
检测了分散在水中的粘性旋覆花、筋骨草、带叶茜草和扩散隔苞草的水提取物以及月桂油的伤口愈合效果。将10%（w/w）Pluronic F127（PF 127）添加到所用制剂中，以改变水性浸提液粘度并稳定油分散液。在小鼠的背部区域制作全层伤口。用不同的制剂处理伤口，间隔12 h，连续2 d处理4次。在16天内，目视观察伤口，解剖学记录并测量伤口面积。第16天后，处死动物并检查伤口区域的组织学。粘土木香提取物的伤口愈合活性最好，其次是Parieteria diffusa、月桂、筋骨草，最差的是Rubia taenifolia。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The wound healing effect of the aqueous extracts of Inula viscosa, Ajuga chia, Rubia taenifolia and Parieteria diffusa, and the oil of Laurus nobilis, dispersed in water, were examined. The 10% (w/w) Pluronic F127 (PF127) was added to the applied preparations, in order to modify the aqueous extracts viscosity, and to stabilize the oil dispersion. A full thickness wound was made in the dorsal area of the mice. The wounds were treated with the different preparations with 12 h intervals for four times in two successive days. For 16 days, the wounds were visually observed, photographically documented and the wound area was measured. After day 16, the animals were sacrificed and the histology of the wound area was examined. The best wound healing activity was observed with the extract of Inula viscosa, followed by Parieteria diffusa, Laurus nobilis, Ajuga chia and the least active extract was that of Rubia taenifolia. (c) 2006 Elsevier Ireland Ltd. All rights reserved.