The contribution of serum osteoprotegerin to bone mass and vertebral fractures in postmenopausal women
The contribution of serum osteoprotegerin to bone mass and vertebral fractures in postmenopausal women
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DOI：
10.1007/s00198-005-1844-1
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发表时间：
2005-11-01
影响因子：
4
通讯作者：
Muñoz-Torres, M
中科院分区：
文献类型：
--
作者：
Mezquita-Raya, P;de la Higuera, M;Muñoz-Torres, M
破骨细胞活性的调节对于了解与绝经后相关的骨丢失至关重要。体外和动物研究揭示了OPG作为诱饵受体的作用，中和了RANKL对破骨细胞分化和激活的影响。然而，OPG-RANKL系统在绝经后骨质疏松症中的作用存在争议。因此，本研究的目的是探讨绝经后妇女循环中OPG、RANKL、骨转换标志物(BTM)、骨密度(BMD)与椎体骨折的关系。对206例平均年龄62岁的绝经后妇女(SD7)进行腰椎(LS)和股骨颈(FN)双X线骨密度仪测量，测定其血中OPG和RANKL、BTM、雌二醇、BMD和既往椎体骨折情况。血清骨钙素水平与年龄(r=0.158；P=0.023)、绝经年限(r=0.167；P=0.016)、骨密度(LS Z分数：r=0.240；P=0.001，FN Z分数：r=0.156；P=0.025)显著相关。超过一半的妇女有未检出的RANKL(n=113；54.9%)。RANKL患者的临床变量、BTM或BMD在可检测和不可检测之间没有显著差异。OPG与骨质疏松(OR：2.9，1.4-5.9)和普遍的椎体骨折(OR：2.5，1.2-5.4)独立相关。我们得出结论，绝经后妇女血清OPG水平与骨量和常见的椎体骨折独立相关。
Regulation of osteoclastic activity is critical for understanding bone loss associated with the postmenopausal period. In vitro and animal studies have revealed the role of OPG as a decoy receptor that neutralizes the effect of RANKL on the differentiation and activation of osteoclasts. However, the role of the OPG-RANKL system in postmenopausal osteoporosis is controversial. Thus, the aim of this study was to investigate the relationship among circulating levels of OPG, RANKL, bone turnover markers (BTM), bone mineral density (BMD) and vertebral fractures in postmenopausal women. We determined anthropometric parameters, circulating OPG and RANKL, BTM, estradiol, BMD by dual X-ray absorptiometry at the lumbar spine (LS) and femoral neck (FN), and pre-existing vertebral fractures in 206 ambulatory postmenopausal women of a mean age of 62 years (SD 7). Circulating OPG was significantly related to age ( r =0.158; P =0.023), years since menopause ( r =0.167; P =0.016) and BMD (LS Z-score: r =0.240; P =0.001, FN Z-score: r =0.156; P =0.025). Over half of the women had undetectable RANKL ( n =113; 54.9%). There were no significant differences in clinical variables, BTM or BMD among women with detectable vs. undetectable RANKL. OPG was found to be independently associated with osteoporosis (OR: 2.9, 1.4-5.9) and prevalent vertebral fractures (OR: 2.5, 1.2-5.4). We conclude that serum OPG levels are independently associated with bone mass and prevalent vertebral fractures in postmenopausal women.