The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages.
The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages.
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DOI：
10.1155/2021/5577577
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发表时间：
2021
影响因子：
4.6
通讯作者：
Wu Z
中科院分区：
文献类型：
--
作者：
Liu S;Yang J;Wu Z
巨噬细胞是一种多功能免疫细胞，其功能依赖于极化表型和微环境。巨噬细胞有两种表型，M1促炎表型和M2抗炎表型，在许多炎症反应和疾病中发挥重要作用。α-酮戊二酸是TCA循环的关键代谢物，可调节巨噬细胞极化表型，在多种炎症相关疾病中发挥抗炎作用。本文就α-酮戊二酸对巨噬细胞的代谢、调控机制及研究前景作一综述。α-酮戊二酸调节巨噬细胞极化可能为预防和治疗炎症性疾病提供一个有希望的靶点，并且有益于动物健康。
Macrophages are multifunctional immune cells whose functions depend on polarizable phenotypes and the microenvironment. Macrophages have two phenotypes, including the M1 proinflammatory phenotype and the M2 anti-inflammatory phenotype, which play important roles in many inflammatory responses and diseases. α-Ketoglutarate is a key metabolite of the TCA cycle and can regulate the phenotype of macrophage polarization to exert anti-inflammatory effects in many inflammation-related diseases. In this review, we primarily elucidate the metabolism, regulatory mechanism, and perspectives of α-ketoglutarate on macrophages. The regulation of macrophage polarization by α-ketoglutarate may provide a promising target for the prevention and therapy of inflammatory diseases and is beneficial to animal health.
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