Leishmaniasis: clinical syndromes and treatment
Leishmaniasis: clinical syndromes and treatment
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DOI：
10.1093/qjmed/hct116
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发表时间：
2014-01-01
影响因子：
13.3
通讯作者：
Satoskar, A. R.
中科院分区：
文献类型：
--
作者：
McGwire, B. S.;Satoskar, A. R.
利什曼病是由利什曼原虫属媒介传播的寄生虫引起的皮肤和内脏人源性疾病和人畜共患疾病的全球术语。这些疾病每年困扰着全球 98 个国家的至少 200 万人，其中超过 3.5 亿人面临风险。这些疾病大多发生在贫困人口身上，预防、诊断和治疗困难。利什曼病的治疗范围从皮肤病变的局部治疗到对播散性皮肤、皮肤粘膜和致命内脏疾病的全身性（通常是有毒的）治疗。本综述总结了利什曼原虫引起的临床综合征以及目前用于各种形式利什曼病的治疗方案。
Leishmaniasis is a global term for cutaneous and visceral anthroponotic and zoonotic diseases caused by the vector-borne parasites of the genus Leishmania. These diseases afflict at least 2 million people each year with more than 350 million at risk in 98 countries worldwide. These are diseases mostly of the impoverished making prevention, diagnosis and treatment difficult. Therapy of leishmaniasis ranges from local treatment of cutaneous lesions to systemic, often toxic, therapy for disseminated cutaneous, mucocutaneous and deadly visceral disease. This review is a summary of the clinical syndromes caused by Leishmania and treatment regimens currently used for various forms of leishmaniasis.