Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women
Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women
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DOI：
10.1210/jc.2007-2128
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发表时间：
2008-03-01
影响因子：
5.8
通讯作者：
Bell, Robin J.
中科院分区：
文献类型：
--
作者：
Davis, Susan R.;Shah, Sonal M.;Bell, Robin J.
内容：已经提出脱氢表雄酮和硫酸脱氢表雄酮（DHEAS）在大脑中发挥神经保护作用，但缺乏这些类固醇的内源性水平和认知功能测量之间的关联的证据。目的：本研究的目的是调查是否循环水平的DHEAS独立地有助于社区妇女的认知功能方面。设计：这是一个以社区为基础的，横断面study.Setting和参与者：二百九十五名妇女，年龄21-77岁，从一个以社区为基础的数据集，并参加了2003年9月和2004年12月。主要观察指标：认知功能综合测试的个体得分和血清DHEAS水平（平方根转换）进行测量。在多元线性回归分析中，DHEAS术语对控制性口语词汇联想测验得分有显著的独立正向贡献，一种执行功能的衡量标准。此外，妇女的DHEAS水平在最高的三分位数谁也有超过12年的教育表现更好的数字跨度向前和数字跨度向后的测试，这是简单的浓度和工作memory.Conclusions测试：更高的内源性DHEAS水平是独立的，有利的执行功能，浓度和工作记忆。
Context: It has been proposed that dehydroepiandrosterone and dehydroepiandrosterone sulfate (DHEAS) exert neuroprotective effects in the brain, yet evidence of associations between the endogenous levels of these steroids and measures of cognitive function is lacking.Objective: The objective of the study was to investigate whether circulating levels of DHEAS independently contribute to aspects of cognitive function in women in the community.Design: This was a community-based, cross-sectional study.Setting and Participants: Two hundred ninety-five women, aged 21-77 yr, were recruited from a community-based data set and participated between September 2003 and December 2004. Women were excluded if they reported any health condition that might potentially adversely affect cognitive function.Main Outcome Measures: The individual scores of a comprehensive battery of tests of cognitive function and the serum level of DHEAS ( square root transformed) were measured.Results: In the multiple linear regression analysis, the DHEAS term made a significant independent positive contribution to the Controlled Oral Word Association Test score, a measure of executive function. In addition, women with a DHEAS level in the highest tertile who also had more than 12 yr of education performed better on both Digit Span Forward and Digit Span Backward tests, which are tests of simple concentration and working memory, respectively.Conclusions: Higher endogenous DHEAS levels are independently and favorably associated with executive function, concentration, and working memory.