Oral acyclovir in the treatment of acute herpes zoster ophthalmicus.
Oral acyclovir in the treatment of acute herpes zoster ophthalmicus.
复制标题
口服阿昔洛韦治疗急性眼部带状疱疹。
DOI：
10.1016/s0161-6420(86)33678-9
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发表时间：
1986
期刊：
影响因子：
13.7
通讯作者：
D. King
中科院分区：
文献类型：
--
作者：
L. Cobo;G. Foulks;T. Liesegang;J. Lass;J. Sutphin;Kirk R. Wilhelmus;Dan B. Jones;S. Chapman;A. Segreti;D. King
Seventy-one nonimmunocompromised patients with herpes zoster ophthalmicus, presenting within seven days of onset of characteristic skin eruption, were enrolled in a prospective, longitudinal, randomized, double-masked, placebo-controlled trial with oral ac yclovir. In a previous interim report we noted more prompt resolution of dermatomal signs and symptoms with acyclovir treatmeet. There was also a reduction of viral shedding in acyclovir-treated patients coupled with a trend to greater rate of microdissemination of the virus in placebotreated patients (Cobo LIVI, et al. Ophthalmology 1985; 92:1574–83). While further substantiating these findings, we report that a ten-day course of treatment with oral acyclovir (600 mg, five times a day) is well-tolerated and significantly reduces the incidence and severity of the most common complications of herpes zoster ophthalmicus: dendritiform keratopathy, stromal keratitis, and uveitis. While this acyclovir treatment regimen reduces the zoster-related pain during the acute phase of the disease, especially in patients treated within 72 hours of onset of skin lesions, it has no evident effect on either incidence, severity, or duration of post-herpetic neuralgia in the patients studied.
