Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution
Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution
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DOI：
10.1002/gcc.20485
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发表时间：
2007-11-01
影响因子：
3.7
通讯作者：
Yokota, Jun
中科院分区：
文献类型：
--
作者：
Nagayama, Kazuhiro;Kohno, Takashi;Yokota, Jun
以100 kb分辨率对43个肺癌细胞系进行全基因组扫描，鉴定出51个纯合缺失（HD）基因组区域。这些区域包含113个基因，包括两个已知的肿瘤抑制基因，RBI（RB）和CDKN 2A（p16），以及8个先前被报道为候选肿瘤抑制基因的基因，如PTPRD和LRPIB。三个miRNA基因，MIRNLET 7 C（let-7 c），MIRN 99 A（hsa-mir-99 a）和MIRN 125 B2（hsa-mir-125 b-2），也被定位在HD的21 q11-q21区域。本研究提供了一个蛋白质和miRNA编码基因的清单，这些基因的失活可能与肺癌发生有关。本文包含可在http://www.interscience.wiley.com/ipages/1045-2257/suppmat上获得的补充材料。(C)2007 Wiley-Liss，Inc.
Whole genome scanning of 43 lung cancer cell lines at a 100-kb resolution led to identification of 51 genomic regions with homozygous deletions (HDs). The regions contained 113 genes, including two known tumor suppressor genes, RBI (RB) and CDKN2A (p16) and eight genes previously reported as being candidate tumor suppressor genes, such as PTPRD and LRPIB. Three miRNA genes, MIRNLET7C (let-7c), MIRN99A (hsa-mir-99a), and MIRN125B2 (hsa-mir-125b-2), were also mapped in a region with HD at 21q11-q21. The present study provides a list of protein- and miRNA-encoding genes whose inactivation is possibly involved in lung carcinogenesis. This article contains Supplementary Material available at http://www.interscience.wiley.com/ipages/1045-2257/suppmat. (C) 2007 Wiley-Liss, Inc.