Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer
Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer
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DOI：
10.1002/ijc.21620
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发表时间：
2006-05-01
影响因子：
6.4
通讯作者：
Hofstädter, F
中科院分区：
文献类型：
--
作者：
Dietmaier, W;Bettstetter, M;Hofstädter, F
Maspin是丝氨酸蛋白酶抑制因子家族的成员之一，在低分化的结直肠肿瘤中高表达，在微卫星不稳定的肿瘤中更常见。免疫组织化学核Maspin染色主要见于此类癌侵袭前沿的肿瘤细胞，提示该分子与局部肿瘤细胞的侵袭和侵袭有关。在一项回顾性研究中，我们用免疫组织化学的方法研究了172例原发III期结肠癌中核Maspin的表达作为一种潜在的预后工具。在172例患者中，76例仅接受手术治疗，96例接受以5-氟尿嘧啶(5-Fu)为基础的辅助化疗。在我们的患者队列中，核Maspin表达是影响总体生存的独立不良预后因素(风险比2.08；95%可信区间1.13-3.81；p=0.018)。然而，与接受辅助治疗的肿瘤不表达Maspin分子的患者相比，在细胞核中表达Maspin的原发肿瘤患者显示出显著的5-FU化疗益处(风险比0.384；95%CI，0.188-0.784；p=0.009)。在晚期结肠癌患者中，核Maspin的表达可高度预测5-FU的化疗疗效。免疫组织化学Maspin表达阴性的患者不能从5-FU治疗中受益，可能是替代(非5-FU为基础的)辅助治疗方案的候选者。(C)2005年Wiley-Liss，Inc.
Maspin, a member of the Serpin protease inhibitor family, is over-expressed in poorly differentiated colorectal tumors and more frequently found in tumors with microsatellite instability. Immunohistochemical nuclear Maspin staining is predominantly seen in tumor cells at the invasion front of such cancers, suggesting that this molecule is associated with local tumor cell infiltration and aggressiveness. In a retrospective study, we studied nuclear Maspin expression as a potential prognostic tool in a total of 172 primary stage III colon cancers by immunohistochemistry. Of those 172 patients, 76 were treated by surgery only, and 96 patients received additional adjuvant 5-fluorouracil (5-FU) based chemotherapy. Nuclear Maspin expression was an independent adverse prognostic factor for overall survival in our patient cohort (hazard ratio 2.08; 95% CI, 1.13-3.81; p = 0.018). However, patients with primary tumors expressing Maspin in the nucleus showed a significant treatment benefit from 5-FU chemotherapy (hazard ratio 0.384; 95% CI, 0.188-0.784; p = 0.009) compared to adjuvantly treated patients whose tumors did not express this molecule. Nuclear Maspin expression is highly predictive of 5-FU chemotherapy response in patients with advanced stage colon cancer. Patients with negative immunhistochemical Maspin expression do not benefit from 5-FU treatment anti may be candidates for an alternative (non-5-FU based) adjuvant therapy regime. (c) 2005 Wiley-Liss, Inc.