Potentially malignant oval lesions in Northern Ireland: a 20-year population-based perspective of malignant transformation
Potentially malignant oval lesions in Northern Ireland: a 20-year population-based perspective of malignant transformation
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DOI：
10.1034/j.1601-0825.2001.70104.x
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发表时间：
2001-01-01
期刊：
影响因子：
3.8
通讯作者：
Kee, F
中科院分区：
文献类型：
--
作者：
Cowan, CG;Gregg, TA;Kee, F
这项基于实验室的回顾性研究调查了 160 万人口口腔粘膜病变恶变的可能性。过去一年中，共有 745 名患者被诊断为原发性口腔内鳞状细胞癌 (OSCC)，165 名患者患有异型增生，1182 名患者患有“非异型增生”病变（上皮增生、角化过度、上皮萎缩、扁平苔藓和红斑狼疮）。诊断后平均间隔分别为 48 个月和 65 个月，15% 的不典型增生和 1% 的“非不典型增生”病变发生恶变。只有 6% 的 OSCC 患者进行了浸润前病变活检。这些数据表明，白色病变很少是 OSCC 的浸润前阶段。因此，早期的变化可能是红色的、小的甚至是微小的，而癌症的发展没有临床可观察到的阶段。更有效的管理策略将需要开发组织标记物以加强早期检测。
This retrospective laboratory-based study investigates the potential for malignant transformation of oral mucosal lesions in a population of 1.6 million. Over the ttl-year period there were 745 patients diagnosed with primary intra-oral squamous cell carcinoma(OSCC), 165 patients with dysplasia and 1182 patients with 'nondysplastic' lesions (epithelial hyperplasia, hyperkeratosis epithelial atrophy, lichen planus and lupus erythematosus). Malignant transformation occurred in 15% of dysplasias and in 1% of 'non-dysplastic' lesions at average intervals after diagnosis of 48 and 65 months respectively, Only 6% of patients with OSCC had a preinvasive lesion biopsied, These data suggest that white lesions are only rarely the pre-invasive phase of OSCC. It is possible therefore that early changes are red, small or even microscopic with carcinoma developing without a clinically observable phase. More effective management strategies will require the development of tissue markers to enhance early detection.