Pulmonary Reimplantation Response
Pulmonary Reimplantation Response
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肺再植反应
DOI：
10.1097/00000658-197301000-00006
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发表时间：
1973
影响因子：
9
通讯作者：
F. Veith
中科院分区：
文献类型：
--
作者：
S. Siegelman;S. Sinha;F. Veith
肺的再植或自体移植是一项涉及许多结构分割的艰巨程序。3‘6“11、18、20’24最近的技术进步使再次移植的肺能够最大限度地减少支气管和血管吻合口的缺陷；2‘22如果支气管和主要血管得到充分的重建，再移植的肺现在可以非常好地恢复正常的形态和功能。这些缺陷在很大程度上是可逆的‘3’21，可能归因于神经、淋巴管和支气管血管的破坏和/或缺血性损伤。1“7”1‘2，8我们一直在使用系列胸片和肺血管造影结合肺活检来研究犬移植肺排斥反应的机制。1’5“6系列胸片是监测术后移植物状态的重要手段。由于对自体移植的预期反应尚未充分确定，因此很难确定术后肺部放射学异常是由于排斥反应还是再植入。进行这项研究是为了使我们能够确定
REIMPLANTATION or autotransplantation of the lung is a formidable procedure involving division of many structures. In the past, reimplantation of the canine lung presented technical problems which resulted in high surgical mortality and appreciable compromise of the bronchial and vascular anastomoses with consequent functional impairments in surviving animals.3'6"11,18,20'24 Recent technical improvements have made it possible to minimize defects at the bronchial and vascular anastomoses;2'22 a reimplanted lung can now recover normal morphology and function remarkably well if the bronchus and major vessels are adequately reconstructed.10'20.23 After technically flawless reimplantation, however, functional defects may occur in the early postoperative period. These defects are largely reversible'3'21 and may be attributed to disruption of nerves, lymphatics and bronchial vessels and/or to ischemic injury.1"7"1'2,8 We have been investigating the mechanisms of pulmonary allograft rejection in dogs using serial chest roentgenography and pulmonary angiography with simultaneous lung biopsy.1'5"6 Serial chest roentgenography is an important means of monitoring the status of the allograft in the postoperative period. Since the anticipated responses to autotransplantation have not been adequately defined, it may be difficult to determine whether a postoperative pulmonary roentgenologic abnormality is due to rejection or reimplantation. The present study was undertaken to allow us to establish