Genetic determinants of glucose homeostasis
Genetic determinants of glucose homeostasis
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DOI：
10.1016/j.beem.2011.12.002
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发表时间：
2012-04-01
影响因子：
7.4
通讯作者：
Wareham, Nicholas J.
中科院分区：
文献类型：
--
作者：
Barker, Adam;Langenberg, Claudia;Wareham, Nicholas J.
2型糖尿病是一种复杂的代谢紊乱，其特征在于不同程度的胰岛素分泌受损和对胰岛素作用的抵抗。最近在了解糖尿病的遗传决定因素方面取得了相当大的进展。合乎逻辑的下一步是描述这些变异如何与导致糖尿病的潜在病理生理过程相关，因为这可能提供对疾病途径的见解。这些数量性状，当然，直接利益本身和越来越多的文献，现在出现的胰岛素分泌和胰岛素抵抗的遗传决定因素。这篇综述文章的重点是描述2型糖尿病风险变异体和定量血糖性状之间的复杂关联，以及最初在这些性状与2型糖尿病风险的关联研究中发现的变异体之间的关系。(C)2012爱思唯尔有限公司保留所有权利。
Type 2 diabetes is a complex metabolic disorder characterised by varying degrees of impairment in insulin secretion and resistance to the action of insulin. Considerable progress has been made recently in understanding the genetic determinants of diabetes. A logical next step is to describe how these variants relate to the underlying pathophysiological processes that lead to diabetes as this may provide insights into pathways to disease. These quantitative traits are, of course, of direct interest in themselves and a growing literature is now emerging on the genetic determinants of insulin secretion and insulin resistance. This review article focuses on describing the complex associations between type 2 diabetes risk variants and quantitative glycaemic traits and the relationship between variants initially discovered in association studies of these traits and risk of type 2 diabetes. (C) 2012 Elsevier Ltd. All rights reserved.