Nativity differences in allostatic load by age, sex, and Hispanic background from the Hispanic Community Health Study/Study of Latinos.
Nativity differences in allostatic load by age, sex, and Hispanic background from the Hispanic Community Health Study/Study of Latinos.
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DOI：
10.1016/j.ssmph.2016.05.003
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Kaplan RC
中科院分区：
文献类型：
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作者：
Salazar CR;Strizich G;Seeman TE;Isasi CR;Gallo LC;Avilés-Santa ML;Cai J;Penedo FJ;Arguelles W;Sanders AE;Lipton RB;Kaplan RC
适应负荷（AL）是机体因累积暴露于压力而产生的生物“磨损”指标，在美国西班牙裔/拉丁裔人群中很少被研究。我们在西班牙裔社区健康研究/拉丁裔研究中调查了年龄、性别和出生的AL积累模式。我们研究了15830名年龄在18-74岁的墨西哥、古巴、多米尼加、波多黎各、中美洲和南美洲血统的西班牙裔/拉丁裔美国人，其中77%是在外国出生的。与AL的概念一致，我们基于16个生理指标开发了一个指数，这些指标涵盖了心脏代谢、副交感神经和炎症系统。我们使用对数线性模型计算了年龄组别（18-44岁、45-54岁、55-74岁）、性别和出生状况的平均调整后的AL评分。在外国出生的个体中，AL在美国居住时间（<10年，≥10年）和移民年龄（<24年，≥24年）的差异也被检查。在55岁以下的人群中，在控制了社会经济和行为因素后，美国出生的人AL最高，在美国居住时间较长的外国出生的西班牙裔/拉丁裔人AL居中（≥10年），在美国居住时间较短的人AL最低（<10年）（P<0.0001，呈上升趋势）。同样，在移民年龄较早的外国出生人群中，人工智能也有所增加。这些趋势在年龄≥55岁的人群中不太明显。在所有西班牙裔/拉丁裔遗传群体中观察到类似的模式（相互作用P =0.5）。我们的研究结果既支持“健康移民”模式，也支持随着时间的推移，不同血统的美国西班牙裔/拉丁裔美国人的健康优势逐渐丧失。美国西班牙裔/拉美裔人的适应负荷积累模式尚未得到充分研究。在所有年龄段，西班牙裔/拉丁裔男性的适应负荷都高于女性。
Allostatic load (AL), an index of biological “wear and tear” on the body from cumulative exposure to stress, has been little studied in US Hispanics/Latinos. We investigated AL accumulation patterns by age, sex, and nativity in the Hispanic Community Health Study/Study of Latinos. We studied 15,830 Hispanic/Latinos of Mexican, Cuban, Dominican, Puerto Rican, Central and South American descent aged 18–74 years, 77% of whom were foreign-born. Consistent with the conceptualization of AL, we developed an index based upon 16 physiological markers that spanned the cardiometabolic, parasympathetic, and inflammatory systems. We computed mean adjusted AL scores using log-linear models across age-groups (18–44, 45–54, 55–74 years), by sex and nativity status. Among foreign-born individuals, differences in AL by duration of residence in the US (<10, ≥10 years) and age at migration (<24, ≥24 years) were also examined. In persons younger than 55 years old, after controlling for socioeconomic and behavioral factors, AL was highest among US-born individuals, intermediate in foreign-born Hispanics/Latinos with longer duration in the US (≥10 years), and lowest among those with shorter duration in the US (<10 years) (P<0.0001 for increasing trend). Similarly, AL increased among the foreign-born with earlier age at immigration. These trends were less pronounced among individuals ≥55 years of age. Similar patterns were observed across all Hispanic/Latino heritage groups (P for interaction=0.5). Our findings support both a “healthy immigrant” pattern and a loss of health advantage over time among US Hispanics/Latinos of diverse heritages. Patterns of allostatic load accumulation in US Hispanics/Latinos is understudied. Hispanic/Latino men had higher allostatic load than women across all ages.