Nationwide increase in hospitalizations and hepatitis C among inpatients with cirrhosis and sequelae of portal hypertension
Nationwide increase in hospitalizations and hepatitis C among inpatients with cirrhosis and sequelae of portal hypertension
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DOI：
10.1016/j.cgh.2007.04.027
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发表时间：
2007-09-01
影响因子：
12.6
通讯作者：
Thuluvath, Paul J.
中科院分区：
文献类型：
--
作者：
Nguyen, Geoffrey C.;Segev, Dorry L.;Thuluvath, Paul J.
背景与目的：晚期肝病及门静脉高压并发症是住院治疗的常见指征。我们的目的是利用具有全国代表性的数据集来描述门静脉高压并发症住院患者的发病率、特征和结局的纵向趋势。方法：采用《国际疾病分类》第九版临床修改诊断代码，对1998 - 2003年全国住院患者样本中因门静脉高压并发症（肝性脑病、腹水或静脉曲张出血）入院的患者进行分析。采用《国际疾病分类第九版临床修改程序代码》对肝移植和门静脉分流手术进行鉴定。全国估计的住院率、住院死亡率和医院收费考虑了调查设计。结果：1998年至2003年期间，住院率每年显著增加5%，特别是在东北部和南部。在这些住院患者中，丙型肝炎相关晚期肝病的患病率从12.9%增加到23.7%，在丙型肝炎合并酒精相关疾病的患者中，患病率从5.6%增加到11.2%。美国以人口为基础的住院死亡率从每10万人1.9上升到2.1
Background & Aims: Advanced liver disease and complications of portal hypertension are common indications for hospitalization. Our objectives were to characterize longitudinal trends in incidence, characteristics, and outcomes of patients hospitalized with complications of portal hypertension using a nationally representative data set. Methods: Admissions for complications of portal hypertension (hepatic encephalopathy, ascites, or variceal bleed) were identified from the Nationwide Inpatient Sample between 1998 and 2003 using International Classification of Diseases, 9th Revision, Clinical Modification diagnosis codes. International Classification of Diseases, 9th Revision, Clinical Modification procedural codes were used to identify liver transplantation and portosystemic shunt procedures. National estimates for incidence of hospitalization over time, in-hospital mortality, and hospital charges accounted for survey design. Results : Hospitalization rates increased significantly by 5% annually between 1998 and 2003, particularly in the Northeast and the South. The prevalence of hepatitis C-related advanced liver disease among these hospitalized patients increased from 12.9% to 23.7%, and in those with HCV and concurrent alcohol-related disease the rate increased from 5.6% to 11.2%. US population-based in-hospital mortality increased modestly from 1.9 to 2.1 per 100,000 (P