Hepatic Venous Pressure Gradient Measurement in Bangladeshi Cirrhotic Patients: A Correlation with Child's Status, Variceal Size, and Bleeding.
Hepatic Venous Pressure Gradient Measurement in Bangladeshi Cirrhotic Patients: A Correlation with Child's Status, Variceal Size, and Bleeding.
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DOI：
10.5005/jp-journals-10018-1235
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发表时间：
2017-07-01
期刊：
影响因子：
--
通讯作者：
Mohammad Fazle Akbar, Sheikh
中科院分区：
文献类型：
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作者：
Al Mahtab, Mamun;M Noor E Alam, Sheikh;Mohammad Fazle Akbar, Sheikh
背景：肝静脉压力梯度（HVPG）反映了肝硬化门静脉高压症患者的门静脉压力。本研究的目的是评估HVPG静脉曲张的大小，Child-Pugh状态，和静脉曲张bleeding.MATERIALS和方法：共96例肝硬化患者前瞻性入选，每个病人的HVPG水平通过经股动脉途径进行测量。对每例受试者进行临床和生化评估以及上消化道（GI）内镜检查。结果：Child B和C级患者的平均HVPG（分别为14.10 ± 7.56和13.64 ± 7.17 mm Hg）高于Child A级患者（10.15 ± 5.63 mm Hg）。HVPG水平在Child A和B类（p = 0.011）以及Child A和C类（p = 0.041）之间存在显著差异。大静脉曲张出血者的平均HVPG也高于非出血者（17.7 ± 5.5 vs 14.9 ± 4.7 mmHg; p = 0.006）。结论：肝静脉压差对评估肝硬化的严重程度似乎很重要。如何引用这篇文章：Al Mahtab M，Noor E Alam SM，Rahim MA，Alam MA，Khondaker FA，Moben AL，Mohsena M，Akbar SMF.孟加拉国肝硬化患者的肝静脉压力梯度测量：与儿童状况、静脉曲张大小和出血的相关性。欧亚肝胃肠道杂志2017;7（2）：142-145。
BACKGROUND: Hepatic venous pressure gradient (HVPG) reflects the portal pressure in patients with cirrhotic portal hypertension. The aim of the study was to assess the relation of HVPG to variceal size, Child-Pugh status, and variceal bleeding.MATERIALS AND METHODS: A total of 96 patients with cirrhosis of liver were enrolled prospectively and each patient's HVPG level was measured via the transfemoral route. Clinical and biochemical evaluation and upper gastrointestinal (GI) endoscopy were done in each subject. Severity of cirrhosis was assessed by Child's status.RESULTS: The mean HVPG was higher in patients with Child's B and C (14.10 ± 7.56 and 13.64 ± 7.17 mm Hg respectively) compared with those of Child's A (10.15 ± 5.63 mm Hg). The levels of HVPG differed significantly between Child's classes A and B (p = 0.011) and Child's A and C (p = 0.041). The mean HVPG was also higher in bleeders compared with nonbleeders with large varices (17.7 ± 5.5 vs 14.9 ± 4.7 mmHg respectively; p = 0.006).CONCLUSION: Hepatic venous pressure gradient seems to be important to assess the severity of liver cirrhosis.How to cite this article: Al Mahtab M, Noor E Alam SM, Rahim MA, Alam MA, Khondaker FA, Moben AL, Mohsena M, Akbar SMF. Hepatic Venous Pressure Gradient Measurement in Bangladeshi Cirrhotic Patients: A Correlation with Child's Status, Variceal Size, and Bleeding. Euroasian J Hepato-Gastroenterol 2017;7(2):142-145.