Rapid Prototyping of a Double-Layer Polyurethane-Collagen Conduit for Peripheral Nerve Regeneration
Rapid Prototyping of a Double-Layer Polyurethane-Collagen Conduit for Peripheral Nerve Regeneration
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DOI：
10.1089/ten.tec.2008.0354
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发表时间：
2009-03-01
影响因子：
3
通讯作者：
Wang, Xiaohong
中科院分区：
文献类型：
--
作者：
Cui, Tongkui;Yan, Yongnian;Wang, Xiaohong
采用双喷嘴低温沉积法制备了一种用于周围神经修复的双层聚氨酯(PU)-胶原神经导管。DLDM系统基于数字原型方法，使用热诱导相分离和冷冻干燥相结合的方法。利用该系统，可以将两种不同性质的生物材料组合在一起，形成内层具有良好的生物相容性，外层具有期望的机械强度的支架结构。成形精度高，壁厚可控，两层紧密连接。研究了改变工艺参数和材料温度对支架结构的影响。此外，还研究了材料浓度对支架的机械强度和亲水性的影响。通过对工艺参数和生物材料浓度的优化，制备出了理想的周围神经修复管道，该管道由PU外层微孔层和内层胶原纤维组成。
A new technique for preparing double-layer polyurethane (PU)-collagen nerve conduits for peripheral nerve repair via a double-nozzle, low-temperature, deposition manufacturing (DLDM) system has been developed. The DLDM system is based on a digital prototyping approach, and uses a combination of thermally induced phase separation and freeze-drying. With this system, two kinds of biomaterials with different properties can be combined to produce scaffold structures with good biocompatibility in the inner layer and with the desired mechanical strength protruded by the outer. The forming precision is high, the wall thickness can be controlled, and a tight connection between the two layers can be achieved. The effects of changing the processing parameters and the material temperature on the structure of the scaffolds have been investigated. Additionally, the effect of material concentration on the mechanical strength and hydrophilic properties of the scaffolds has also been studied. Ideal peripheral nerve repair conduits, comprising an outer microporous layer of PU and internal oriented filaments of collagen, have been manufactured through optimizing the processing parameters and the biomaterial concentrations.