Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena .2. Three-dimensional structure in solution
Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena .2. Three-dimensional structure in solution
复制标题
DOI：
10.1023/a:1026314722607
复制
发表时间：
1997-08-01
期刊：
影响因子：
--
通讯作者：
Gu, XC
中科院分区：
文献类型：
--
作者：
Qu, YX;Liang, SP;Gu, XC
用500和600 MHz的二维H-1 NMR数据测定了虎纹捕鸟蛛毒素-I在水溶液中的三维结构。用XPLOR 3.1程序计算了由NOE推断的质子间距离和由自旋-自旋耦合常数推断的二面角组成的结构约束。最好的10个结构都有NOE违规
The three-dimensional structure in aqueous solution of native huwentoxin-I, a neurotoxin from the venom of the spider Selenocosmia huwena, has been determined from two-dimensional H-1 NMR data recorded at 500 and 600 MHz, Structural constraints consisting of interproton distances inferred from NOEs and dihedral angles from spin-spin coupling constants were used as input for distance geometry calculation with the program XPLOR 3.1. The best 10 structures have NOE violations