Injectable nanocarriers for biodetoxification
Injectable nanocarriers for biodetoxification
复制标题
DOI：
10.1038/nnano.2007.339
复制
发表时间：
2007-11-01
影响因子：
38.3
通讯作者：
Leroux, Jean-Christophe
中科院分区：
文献类型：
--
作者：
Leroux, Jean-Christophe
医院通常治疗因非法药物消费、自杀企图或意外接触而过量服用药物或其他有毒化学品的病人。然而，对于许多危及生命的情况，没有特定的解毒剂，治疗主要基于排空胃、施用活性炭或其他中毒支持的一般措施。一个有前途的策略，管理这种过量是注射纳米载体，可以提取有毒物质从中毒组织。为了有效，纳米载体必须在血液中保持足够长的时间以隔离有毒组分和/或其代谢物，并且毒素结合的复合物也必须保持稳定，直到其从血流中去除。在这里，我们讨论的原则，管理使用可注射的纳米载体在生物解毒和审查的药理学性能的一些不同的方法。
Hospitals routinely treat patients suffering from overdoses of drugs or other toxic chemicals as a result of illicit drug consumption, suicide attempts or accidental exposures. However, for many life- threatening situations, specific antidotes are not available and treatment is largely based on emptying the stomach, administering activated charcoal or other general measures of intoxication support. A promising strategy for managing such overdoses is to inject nanocarriers that can extract toxic agents from intoxicated tissues. To be effective, the nanocarriers must remain in the blood long enough to sequester the toxic components and/ or their metabolites, and the toxin bound complex must also remain stable until it is removed from the bloodstream. Here, we discuss the principles that govern the use of injectable nanocarriers in biodetoxification and review the pharmacological performance of a number of different approaches.