Rat chorionic gonadotropin: augmentation of bioactivity in the absence of the pituitary.
Rat chorionic gonadotropin: augmentation of bioactivity in the absence of the pituitary.
复制标题
大鼠绒毛膜促性腺激素：在垂体缺失的情况下增强生物活性。
作者：
M. Blank;M. Dufau
通过大鼠间质细胞睾酮测定，在怀孕大鼠的血清和胎盘中存在显著的促性腺素样生物活性。这种假定的大鼠绒毛膜促性腺激素(RCG)在血清和胎盘中的活性模式与观察到的大鼠胎盘催乳素(RPL)放射受体活性不同。妊娠第12天摘除母体后，胎盘和血清RCG(和RPL)活性显著增加，胎盘重量也显著增加。这些发现加强了大鼠CG存在的证据，并表明在正常妊娠期间，母鼠脑下垂体在调节胎盘功能方面发挥了新的作用。
Significant gonadotropin-like bioactivity, as measured by rat interstitial cell testosterone assay, is present in the serum and placenta of pregnant rats. The patterns of activity for this putative rat chorionic gonadotropin (rCG) in serum and placenta are distinct from those observed for rat placental lactogen (rPL) radioreceptor activity. Placental and serum rCG (and rPL) activities are substantially increased, as are placental weights, following removal of the maternal pituitary on day 12 of pregnancy. These findings strengthen the evidence for the existence of a rat CG and suggest a novel role for the maternal pituitary in regulating placental function during normal gestation.