Temporal events regulating the early phases of the mammalian cell cycle.
Temporal events regulating the early phases of the mammalian cell cycle.
复制标题
调节哺乳动物细胞周期早期阶段的时间事件。
DOI：
10.1016/0955-0674(91)90150-w
复制
发表时间：
1991
影响因子：
7.5
通讯作者：
Lee,AS
中科院分区：
文献类型：
--
作者：
Naeve,GS;Sharma,A;Lee,AS
有人认为，调控哺乳动物细胞周期进程的通路涉及几个癌基因。现对其中一些调控癌基因(fos、jun、myc和Rb-1)以及它们在细胞从G0到G1和G1到S的过程中可能发挥的作用进行综述。关于两个复制依赖基因的数据，分别编码组蛋白和胸苷激酶，也被作为描述G1-S边界转录和转录后事件的模型。
It is proposed that the regulation of the pathways directing mammalian cell cycle progression involves several oncogenes. A summary of what is known about some of these regulatory oncogenes (fos, jun, myc, andRb-1) and where they might function in the progression of a cell from G0 to G1 and G1 to S is presented. Data on two replication-dependent genes, those encoding histones and thymidine kinase, respectively, are also presented as models for describing transcriptional and post-transcriptional events at the G1-S border.