Myocardial tissue engineering: in vitro models.
Myocardial tissue engineering: in vitro models.
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DOI：
10.1101/cshperspect.a014076
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发表时间：
2014-03
影响因子：
5.4
通讯作者：
Gordana Vunjak Novakovic;T. Eschenhagen;C. Mummery
中科院分区：
文献类型：
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作者：
Gordana Vunjak Novakovic;T. Eschenhagen;C. Mummery
体外综合人体生理学建模是一项艰巨的任务，目前还没有任何现有的细胞/组织系统实现。然而，组织工程在真实再现组织发育、再生和疾病进展的实际环境环境以及提供对形态发生事件的实时洞察方面正变得越来越成功。将生物保真度与高通量筛选和生理反应实时测量相结合的功能性人体组织单元有望改变药物筛选和疾病预测建模。在这篇综述中，我们重点介绍了模拟心脏组织的功能性人心肌的体外工程，用于心肌功能分析，生理学研究，治疗药物筛选和安全药理学。
Modeling integrated human physiology in vitro is a formidable task not yet achieved with any of the existing cell/tissue systems. However, tissue engineering is becoming increasingly successful at authentic representation of the actual environmental milieu of tissue development, regeneration and disease progression, and in providing real-time insights into morphogenic events. Functional human tissue units engineered to combine biological fidelity with the high-throughput screening and real-time measurement of physiological responses are poised to transform drug screening and predictive modeling of disease. In this review, we focus on the in vitro engineering of functional human myocardium that mimics heart tissue for analysis of myocardial function, in the context of physiological studies, drug screening for therapeutics, and safety pharmacology.