A novel acute-phase marker: Lipopolysaccharide binding protein (LBP)
A novel acute-phase marker: Lipopolysaccharide binding protein (LBP)
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DOI：
10.1515/cclm.1999.047
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发表时间：
1999-03-01
影响因子：
6.8
通讯作者：
Zweigner, J
中科院分区：
文献类型：
--
作者：
Schumann, RR;Zweigner, J
急性时相蛋白是非常有用的标志物，用于指示生物体内稳态的紊乱和用于监测疾病的过程。尽管有几种血清急性期标志物可用，但仍然需要更好和更特异性地预测脓毒症和相关疾病，如全身炎症反应综合征（SIRS），因为这些疾病仍然具有高死亡率，并且必须早期和高特异性地检测。在这里介绍了一种新的急性时相蛋白，它在宿主防御中具有一定的生物学功能，可能是一种有用的补充，用于脓毒症的诊断和监测。内毒素结合蛋白（LBP）是一种能够结合并转运细菌内毒素的1类急性时相蛋白。血清LBP水平的变化对宿主对内毒素刺激的反应能力和抵抗脓毒症的能力有深远的影响。从体外研究和动物模型获得的结果在这里进行审查，并对正在进行的临床研究的角度。有证据表明，LBP，沿着其他LPS识别分子，是监测急性期和宿主对LPS攻击反应能力的重要参数。
Acute phase proteins are extremely helpful markers for indicating a disturbance of the homeostasis within the organism and for monitoring the course of a disease. Despite the availability of several serum acute phase markers, a better and more specific prediction of sepsis and related disorders, such as systemic inflammatory response syndrome (SIRS) is still needed, as these diseases still have a high mortality rate and have to be detected early and with high specificity. Here a novel acute-phase protein is introduced, that has certain biological functions in host defense and that may be a useful addition for the diagnosis and monitoring of sepsis. Lipopolysaccharide (LPS or endotoxin), binding protein (LBP) is a class 1 acute-phase protein with the ability to bind and transfer bacterial LPS. Changes in serum levels of LBP have profound effects on the host's ability to react to endotoxin stimulation and to defend itself against sepsis. Results obtained from in vitro studies and from an animal model are reviewed here and a perspective on ongoing clinical studies is given. There is evidence that LBP, along with other LPS-recognizing molecules, is an important parameter for monitoring the acute phase and the ability of the host to react to LPS-challenge.