Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes
Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes
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DOI：
10.3967/bes2018.013
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发表时间：
2018-02-01
影响因子：
3.5
通讯作者：
Lu Jie Li
中科院分区：
文献类型：
--
作者：
Cheng Di;Du Rui;Lu Jie Li
目的探讨无糖尿病人群血清尿酸水平与心血管疾病风险的关系。方法我们调查了来自中国上海嘉定区的8252名年龄bb0 = 40岁无糖尿病的参与者的血清尿酸水平与流行心脏代谢疾病风险、10年冠心病Framingham风险和10年动脉粥样硬化性心血管疾病（ASCVD）风险之间的关系。结果身体质量指数、腰围、血糖、糖化血红蛋白、血压和血脂在不同性别的尿酸四分位数中逐渐升高（P趋势均< 0.05）。与最低四分位数的个体相比，高四分位数的个体肥胖、高血压和血脂异常的患病率明显更高（P趋势均< 0.05）。一项完全调整的逻辑回归分析显示，与尿酸最低四分位数的人相比，尿酸最高四分位数的人患预测心血管疾病的风险更高。高Framingham风险的最高四分位数的多因素调整优势比（ORs）[95%可信区间（CIs）]在男性中为3.00(2.00-4.50)，在女性中为2.95（1.08-8.43）。高ASCVD风险最高四分位数的多因素调整后ORs （95% ci）为男性1.93(1.17-3.17)，女性4.53（2.57-7.98）。结论血清尿酸水平与中国无糖尿病成年人普遍肥胖、高血压、血脂异常、10年冠心病Framingham风险和10年ASCVD风险增加相关。
Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes.Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases (ASCVD) among 8,252 participants aged >= 40 years without diabetes from Jiading district, Shanghai, China.Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid (all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia (all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios (ORs) [95% confidence intervals (CIs)] for the highest quartiles for high Framingham risk were 3.00 (2.00-4.50) in men and 2.95 (1.08-8.43) in women. The multivariate adjusted ORs (95% CIs) for the highest quartile for high ASCVD risk were 1.93 (1.17-3.17) in men and 4.53 (2.57-7.98) in women.Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes.