Prophylactic and therapeutic treatment of graft-versus-host disease in Japan
Prophylactic and therapeutic treatment of graft-versus-host disease in Japan
复制标题
日本移植物抗宿主病的预防和治疗
DOI：
--
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发表时间：
2015
影响因子：
2.1
通讯作者：
M. Murata
中科院分区：
文献类型：
--
作者：
M. Murata
Allogeneic hematopoietic stem cell transplantation in Japan is very different from that in Western countries in terms of the homogeneous genetic background, the preference for bone marrow to peripheral blood stem cells, use of a single unit in cord blood transplantation, and frequent use of non-myeloablative preconditioning due to a large number of elderly patients. Therefore, conclusions obtained from well-designed prospective and/or comparative studies of treatment of graft-versus-host disease (GVHD) performed in the United States or Europe may not fit Japanese transplant patients. This article reviews the studies of prophylactic and therapeutic treatment of acute and chronic GVHD that have been conducted in Japan. A randomized study demonstrated a lower incidence of acute GVHD in tacrolimus-based prophylaxis than in cyclosporine A-based prophylaxis. Retrospective and non-randomized prospective studies suggest that cyclosporine A-based and tacrolimus-based GVHD prophylaxis regimens are well researched and nearly optimized for Japanese patients, including infusion methods and target blood concentration. However, most other studies were performed in a single institute including a small number of patients, resulting in biased conclusions. There is no conclusive report on steroid-refractory acute and chronic GVHD. This review provides a baseline for starting prospective studies to create new evidence for GVHD treatment from Japan.
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影响因子：
20.3
作者：
Soiffer, Robert J.;LeRademacher, Jennifer;Eapen, Mary
通讯作者：
Eapen, Mary
影响因子：
20.3
作者：
P. Martin;G. Schoch;L. D. Fisher;Vera Byers;C. Anasetti;F. Appelbaum;Patrick G. Beatty;K. Doney;George B. McDonald;J. Sanders;K. Sullivan;R. Storb;E. Thomas;R. Witherspoon;Pavel Lomen;John Hannigan;J. Hansen
通讯作者：
P. Martin;G. Schoch;L. D. Fisher;Vera Byers;C. Anasetti;F. Appelbaum;Patrick G. Beatty;K. Doney;George B. McDonald;J. Sanders;K. Sullivan;R. Storb;E. Thomas;R. Witherspoon;Pavel Lomen;John Hannigan;J. Hansen
影响因子：
4.3
作者：
Perkins, Janelle;Field, Teresa;Anasetti, Claudio
通讯作者：
Anasetti, Claudio
DOI：
10.1056/nejmoa1108188
发表时间：
2011-12-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Koreth J;Matsuoka K;Kim HT;McDonough SM;Bindra B;Alyea EP 3rd;Armand P;Cutler C;Ho VT;Treister NS;Bienfang DC;Prasad S;Tzachanis D;Joyce RM;Avigan DE;Antin JH;Ritz J;Soiffer RJ
通讯作者：
Soiffer RJ
影响因子：
4.3
作者：
Chien, Jason W.;Duncan, Steven;Williams, Kirsten M.;Pavletic, Steven Z.
通讯作者：
Pavletic, Steven Z.