LACK OF RESPONSE TO SURAMIN IN PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX
LACK OF RESPONSE TO SURAMIN IN PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX
复制标题
DOI：
10.1016/0002-9343(87)90108-2
复制
发表时间：
1987-03-23
影响因子：
5.9
通讯作者：
GOTTLIEB, MS
中科院分区：
文献类型：
--
作者：
KAPLAN, LD;WOLFE, PR;GOTTLIEB, MS
Forty-one homosexual men with the acquired immune deficiency syndrome (AIDS) or AIDS-related complex were treated with 0.5, 1.0, or 1.5 g of suramin weekly for up to six months. In no patient was evidence of symptomatic improvement or regression of Kaposi''s sarcoma shown. Opportunistic infections developed in 16 patients during therapy. Only six patients (15 percent) became human immunodeficiency virus (HIV) culture-negative during treatment, despite documentation of adequate serum suramin levels. All but one of these six have had disease progression. Decrease in the numbers of total T4 cells with time were observed in both AIDS and AIDS-related complex subgroups. Toxicity was significant and consisted to fatigue, fever, and hepatic and renal dysfunction, all of which were observed most frequently with the 1.0 or 1.5 g dosages. Fatal hepatic failure developed in two patients, and adrenal insufficiency was documented in eight patients. Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease.
