Potential role of immunosenescence in cancer development
Potential role of immunosenescence in cancer development
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DOI：
10.1111/j.1749-6632.2009.05370.x
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Larbi, Anis
中科院分区：
文献类型：
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作者：
Fulop, Tamas;Kotb, Rami;Larbi, Anis
大多数癌症的发病率和流行率随着年龄的增长而增加。其原因可能包括肿瘤逃逸机制和免疫监视减少，但大多数科学家认为，大多数原因是致癌所需的时间。免疫系统是防御病原体和可能的癌症的独特机制;然而，有大量证据表明老年人的免疫系统受到侵蚀，这种现象称为免疫衰老。人们越来越关注免疫衰老以及它如何导致癌症数量随着年龄的增长而增加。免疫系统的每一个分支，先天的和适应性的，都随着年龄的增长而改变，从而导致肿瘤发生的增加。了解免疫衰老对癌症发展和进展的贡献可能会为老年人提供更好的干预措施。
The incidence and prevalence of most cancers increase with age. The reasons for this may include tumor escape mechanisms and decreased immunosurveillance, but most are caused by the time required for carcinogenesis, according to most scientists. The immune system is a unique mechanism of defense against pathogens and possibly cancers; however, there is a body of evidence that the immune system of the aged is eroded, a phenomenon termed immunosenescence. There is a growing interest in immunosenescence and how it may contribute to the increased number of cancers with aging. Each arm of the immune system, innate and adaptive, is altered with aging, contributing to increased tumorigenesis. Understanding the contribution of immunosenescence to cancer development and progression may lead to better interventions for the elderly.