Immune checkpoint therapy for pancreatic cancer.
Immune checkpoint therapy for pancreatic cancer.
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DOI：
10.3748/wjg.v22.i43.9457
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发表时间：
2016-11-21
影响因子：
4.3
通讯作者：
Ansari D
中科院分区：
文献类型：
--
作者：
Johansson H;Andersson R;Bauden M;Hammes S;Holdenrieder S;Ansari D
胰腺癌需要新的治疗方式。免疫检查点抑制的免疫疗法已在其他实体瘤中显示出效果，并且可能在胰腺癌治疗中占有一席之地。大多数针对胰腺癌免疫检查点抑制剂的临床研究尚未完成，仍在招募患者。在已完成的试验中，有一些初步的发现，例如在单一或联合疗法中使用免疫检查点抑制剂治疗后，延迟了疾病进展并提高了总体生存率。然而，由于样本量较小，主要结果尚未确定。本文提供了胰腺癌免疫检查点抑制的临床概述。系统检索了 PubMed、ClinicalTrials.gov 和美国临床肿瘤学会的会议摘要以查找相关临床研究。详细确定并分析了四篇文章、五篇摘要和 25 项临床试验。
Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic cancer. PubMed, ClinicalTrials.gov and American Society of Clinical Oncology’s meeting abstracts were systematically searched for relevant clinical studies. Four articles, five abstracts and 25 clinical trials were identified and analyzed in detail.
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影响因子：
7.2
作者：
Brunet LR;Hagemann T;Andrew G;Mudan S;Marabelle A
通讯作者：
Marabelle A
DOI：
10.1084/jem.20090847
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Francisco LM;Salinas VH;Brown KE;Vanguri VK;Freeman GJ;Kuchroo VK;Sharpe AH
通讯作者：
Sharpe AH
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
DOI：
10.1073/pnas.192461099
发表时间：
2002-09-17
影响因子：
11.1
作者：
Iwai, Y;Ishida, M;Minato, N
通讯作者：
Minato, N
影响因子：
32.4
作者：
Butte, Manish J.;Keir, Mary E.;Freeman, Gordon J.
通讯作者：
Freeman, Gordon J.