Anti-obesity and hypolipidemic effects ofFuzhuan brick tea water extract in high-fat diet-induced obese rats
Anti-obesity and hypolipidemic effects ofFuzhuan brick tea water extract in high-fat diet-induced obese rats
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DOI：
10.1002/jsfa.5887
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发表时间：
2013-04-01
影响因子：
4.1
通讯作者：
Hu, Jiehui
中科院分区：
文献类型：
--
作者：
Li, Qin;Liu, Zhonghua;Hu, Jiehui
研究背景茯砖茶是一种微生物发酵茶，近年来因其对人体健康的益处而受到越来越多的关注。本研究探讨了茯苓砖茶水提物的减肥和降血脂作用。结果FTE由204.07 +/- 3.38 mg g1多酚、109.20 +/- 1.36 mg g1黄酮和其他组成。FTEs显著抑制了高脂饮食肥胖大鼠体重的增加和脂肪组织的积累，并降低了血清三酰甘油、总胆固醇和低密度脂蛋白（LDL）胆固醇的水平。此外，FTEs减弱了固醇调节元件结合蛋白1c、脂肪酸合成酶和CCAAT/增强子结合蛋白的基因表达，这与脂肪生成代谢有关。与此相反，参与能量消耗和脂肪分解的酶的基因表达，包括肝过氧化物酶体增殖物激活受体，肉毒碱棕榈酰转移酶1a和LDL受体基因表达的FTE治疗增加。结论FTEs具有抗肥胖和降血脂的作用，可能是治疗肥胖和高血脂的有效药物。(C)2012年化学工业协会
Background Fuzhuan brick tea is a kind of microbial fermented tea, which has received increasing attention in recent years owing to its benefits for human health. In this study, the anti-obesity and hypolipidemic effects of Fuzhuan brick tea water extracts (FTEs) were investigated. Results FTEs consisted of 204.07 +/- 3.38 mg g1 polyphenol, 109.20 +/- 1.36 mg g1 flavonoids, and others. The FTEs significantly suppressed the increase of body weight and accumulation of adipose tissue, and reduced the level of serum triacylglycerol, total cholesterol and low-density lipoprotein (LDL) cholesterol in obese rats fed a high-fat diet. Moreover, FTEs attenuated the gene expression of sterol regulatory element binding protein-1c, fatty acid synthase and CCAAT/enhancer binding protein , which is related to lipogenic metabolism. In contrast, the gene expressions of enzymes involved in energy expenditure and lipodieresis including hepatic peroxisome proliferator-activated receptor , carnitine palmitoyltransferase 1a and LDL receptor gene expression were increased by FTE treatment. Conclusions Our study demonstrates that FTEs have anti-obesity and hypolipidemic functions, suggesting that it might be effective for treatment of obesity and hyperlipemia. (C) 2012 Society of Chemical Industry