EXERCISE-INDUCED CHANGES IN INSULIN-LIKE GROWTH-FACTORS AND THEIR LOW-MOLECULAR-WEIGHT BINDING-PROTEIN IN HEALTHY-SUBJECTS AND PATIENTS WITH GROWTH-HORMONE DEFICIENCY
EXERCISE-INDUCED CHANGES IN INSULIN-LIKE GROWTH-FACTORS AND THEIR LOW-MOLECULAR-WEIGHT BINDING-PROTEIN IN HEALTHY-SUBJECTS AND PATIENTS WITH GROWTH-HORMONE DEFICIENCY
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DOI：
10.1111/j.1365-2362.1990.tb01857.x
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发表时间：
1990-06-01
影响因子：
5.5
通讯作者：
HALL, K
中科院分区：
文献类型：
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作者：
BANG, P;BRANDT, J;HALL, K
在自行车测力计上进行 30 分钟的中等体育锻炼期间，测定了 6 名健康受试者和 4 名 GH 缺乏症患者的胰岛素样生长因子 1 和 2（IGF-1 和 IGF-2）、低分子量形式的 IGF 结合蛋白（IGFBP-1）、胰岛素、C 肽和 GH 的血清浓度。负荷相当于个体最大摄氧量的 60%。 IGF-1 和 IFG-2 通过放射免疫测定法测定，该测定法是用从免疫母鸡蛋黄中分离出的抗体开发的，在测定前通过自动酸性凝胶过滤分离血清样品。健康人群中 IGF-1（157 .+-. 24 至 196 .+-. 29 .mu.g l-1，P < 0.05）和 IGF-2（451 .+-. 37 至 678 .+-. 85 .mu.g l-1，P < 0.01）的血清浓度（平均值 .+-. SEM）显着增加受试者运动 10 分钟后。平均增长百分比为 26 .+-。 IGF-1 为 5%，50 .+-。 IGF-2 为 11%。未发现与 GH 释放相关的情况。在 GH 缺乏的患者中，平均 IGF-2 浓度上升了 48.+-。比基础 216 .+- 低 17%。 63.mu.g l-1 至峰值浓度 324.+-。 30 分钟后为 115 .mu.g l-1 (P < 0.01)，而 38 .+-. IGF-1 较基础 36 .+- 增加 20%。 13.mu.g l-1 至峰值浓度 55.+-。 27.mu.g l-1 不显着。运动期间血清 IGFBP-1 浓度没有变化，而健康受试者和 GH 缺乏患者的胰岛素和 C 肽浓度以及血糖均下降。总之，运动引起 IGF-1 和 IGF-2 血清浓度的增加，与 GH 反应无关。可以假设 IGF 在将葡萄糖转运到工作肌肉中具有生理作用。
Serum concentrations of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2), the low molecular weight form of IGF binding protein (IGFBP-1), insulin, C-peptide and GH were determined in six healthy subjects and four patients with GH deficiency during 30 min of moderate physical exercise on the cycle ergometer. The load corresponded to 60% of individual maximal oxygen uptake. IGF-1 and IFG-2 were determined by radioimmunoassays developed with antibodies isolated from immunized hens egg-yolk after separation by automated acid gel filtration of serum samples prior to assay. Significant increases in the serum concentrations (mean .+-. SEM) of IGF-1 (157 .+-. 24 to 196 .+-. 29 .mu.g l-1, P < 0.05) and IGF-2 (451 .+-. 37 to 678 .+-. 85 .mu.g l-1, P < 0.01) were seen in the healthy subjects after 10 min of exercise. The mean percentage increase was 26 .+-. 5% for IGF-1 and 50 .+-. 11% for IGF-2. No relation to the GH release was found. In GH-deficient patients the mean IGF-2 concentration rose 48 .+-. 17% from basal 216 .+-. 63 .mu.g l-1 to a peak concentration of 324 .+-. 115 .mu.g l-1 (P < 0.01) after 30 min, while the 38 .+-. 20% rise of IGF-1 from basal 36 .+-. 13 .mu.g l-1 to a peak concentration of 55 .+-. 27 .mu.g l-1 was not significant. The serum IGFBP-1 concentration did not change during exercise, while insulin and C-peptide concentrations, as well as blood glucose, decreased in both healthy subjects and GH-deficient patients. In conclusion, exercise induced an increase in the serum concentration of IGF-1 and IGF-2 independently of the GH response. It may be hypothesized that IGFs have a physiological role in the glucose transport into working muscles.