Efficient MoS2 Exfoliation by Cross-β-Amyloid Nanotubes for Multistimuli-Responsive and Biodegradable Aqueous Dispersions.
Efficient MoS2 Exfoliation by Cross-β-Amyloid Nanotubes for Multistimuli-Responsive and Biodegradable Aqueous Dispersions.
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DOI：
10.1002/anie.201509953
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发表时间：
2016-06
影响因子：
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通讯作者：
Nidhi Kapil;Ashmeet Singh;Manish Singh;D. Das
中科院分区：
文献类型：
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作者：
Nidhi Kapil;Ashmeet Singh;Manish Singh;D. Das
在本文中，我们报告了在水介质中通过短阳离子肽纳米管有效剥离MoS 2，所述短阳离子肽纳米管具有β-淀粉样蛋白（Aβ 1-42）的成核核心（17）LVFFA（21），A β 1-42是与阿尔茨海默病相关的序列。形态，长度和性质的淀粉样蛋白表面上的剥落/分散的二硫化钼的作用进行了研究，通过特定的突变的淀粉样蛋白序列。值得注意的是，由于两种成分的性质，自组装的软纳米结构和二硫化钼，混合分散体可逆地响应于各种刺激，包括温度，pH值和光。蛋白酶的添加导致分散体的损失，否则分散体在环境条件下稳定数月。肽序列的设计灵活性，沿着刺激响应性和生物降解性，可以补充MoS 2在不同领域的应用。
Herein, we report the efficient exfoliation of MoS2 in aqueous medium by short cationic peptide nanotubes featuring the nucleating core (17) LVFFA(21) of β-amyloid (Aβ 1-42), a sequence associated with Alzheimer's disease. The role of morphology, length, and nature of the amyloid surface on exfoliation/dispersions of MoS2 were investigated through specific mutations of the amyloid sequences. Notably, owing to the properties of both the constituents, self-assembled soft nanostructures and MoS2 , the hybrid dispersions responded reversibly to various stimuli, including temperature, pH, and light. Addition of a protease resulted in loss of the dispersions, which are otherwise stable for months at ambient conditions. The design flexibility of the peptide sequences, along with the stimuli-responsiveness and biodegradability, can complement the applications of MoS2 in diverse fields.