Translational control in endothelial cells
Translational control in endothelial cells
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DOI：
10.1016/j.jvs.2007.02.033
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发表时间：
2007-06-01
影响因子：
4.3
通讯作者：
Kraiss, Larry W.
中科院分区：
文献类型：
--
作者：
Brant-Zawadzki, Peter B.;Schmid, Douglas I.;Kraiss, Larry W.
细胞的表型和功能最终由来自基因蓝图的蛋白质的合成决定。基因表达的控制发生在多个检查点，包括DNA转录成RNA和RNA翻译成蛋白质。翻译控制机制是细胞表型的重要调控机制，控制着细胞总基因表达的10%，但与转录控制机制相比，它们的研究仍然相对较少。信使RNA转录本对蛋白质合成的特定调节使细胞能够暂时将翻译与转录分离，并提供了一种比转录所需的更快地对环境信号做出反应的机制。我们讨论了翻译控制的一些基本概念，研究它的工具以及它与血管细胞，特别是血管内皮细胞的相关性。
Cellular phenotype and function is ultimately determined by the synthesis of proteins derived from a genetic blueprint. Control of gene expression occurs at multiple checkpoints, including the transcription of DNA into RNA and the translation of RNA into protein. Translational control mechanisms are important regulators of cellular phenotype, controlling up to 10% of overall cellular gene expression, yet they remain relatively understudied when compared with transcriptional control mechanisms. Specific regulation of protein synthesis from messenger RNA transcripts allows cells to temporally unlink translation from transcription and provides a mechanism for a more rapid response to environmental signals than if transcription were required. We discuss some of the fundamental concepts of translational control, tools for studying it and its relevance to vascular cells, in particular the endothelium.