Electrospinning Bombyx mori silk with poly(ethylene oxide)
Electrospinning Bombyx mori silk with poly(ethylene oxide)
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DOI：
10.1021/bm025581u
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发表时间：
2002-11-01
影响因子：
6.2
通讯作者：
Kaplan, DL
中科院分区：
文献类型：
--
作者：
Jin, HJ;Fridrikh, SV;Kaplan, DL
用于形成纳米级直径纤维的静电纺丝已被探索用于高性能过滤器和用于血管移植物或伤口敷料的生物材料支架。纳米级直径的纤维由于表面积大而具有优势。在本研究中，我们探索静电纺丝技术以蛋白质为基础的生物材料，利用再生蚕丝（Bombyx mori）溶液来制造支架和膜。为了改善蛋白质溶液的加工性能，将分子量为900 000的聚环氧乙烷(PEO)与丝素蛋白混合。成功地静电纺丝了多种成分的丝/PEO水性共混物。使用高分辨率扫描电子显微镜表征纤维的形态。纤维直径均匀且小于800 nm。组成通过估计。 X 射线光电子能谱表征丝/PEO 表面含量。丝和丝/PEO 共混物的水基静电纺丝为基于这种独特纤维蛋白的生物材料支架的制造提供了潜在有用的选择。
Electrospinning for the formation of nanoscale diameter fibers has been explored for high-performance filters and biomaterial scaffolds for vascular grafts or wound dressings. Fibers with nanoscale diameters provide benefits due to high surface area. In the present study we explore electrospinning for protein-based biomaterials to fabricate scaffolds and membranes, from regenerated silkworm silk, Bombyx mori, solutions. To improve processability of the protein solution, poly(ethylene oxide) (PEO) with molecular weight of 900 000 was blended with the silk fibroin. A variety of compositions of the silk/PEO aqueous blends were successfully electrospun. The morphology of the fibers was characterized using high-resolution scanning electron microscopy. Fiber diameters were uniform and less than 800 nm. The composition was estimated by. X-ray photoelectron spectroscopy to characterize silk/PEO surface content. Aqueous-based electrospining of silk and silk/PEO blends provides potentially useful options for the fabrication of biomaterial scaffolds based on this unique fibrous protein.