Ontogenetic aspects of phospholipid-sensitive calcium-dependent protein kinase in guinea pig tissues.
Ontogenetic aspects of phospholipid-sensitive calcium-dependent protein kinase in guinea pig tissues.
复制标题
豚鼠组织中磷脂敏感的钙依赖性蛋白激酶的个体发育方面。
DOI：
10.1016/0006-291x(81)91760-5
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发表时间：
1981
影响因子：
3.1
通讯作者：
Kuo,JF
中科院分区：
文献类型：
--
作者：
Wise,BC;Andersson,RG;Mackerlova,L;Raynor,RL;Solomonsson,I;Kuo,JF
研究了发育中豚鼠各组织中磷脂敏感性钙依赖性蛋白激酶活性水平的变化。胎儿大脑皮层、小脑、中脑、脾脏和肾脏的酶活性水平低于相应的成人组织。相反，胎儿肝脏和视网膜的酶水平较高。另一方面，回肠、心脏和肺的活性水平在发育过程中没有改变。个体发育相关的酶的变化是不同的cAMP和cGMP依赖性蛋白激酶以前报道的，这表明单独的功能作用的新认识的钙离子靶酶。
Changes in the activity levels of phospholipid-sensitive Ca2+-dependent protein kinase in various tissues from developing guinea pigs were investigated. The fetal cerebral cortex, cerebellum, midbrain, spleen and kidney contained lower levels of the enzyme activity compared to the corresponding adult tissues. Conversely, higher enzyme levels were noted for the fetal liver and retina. The activity levels in the ileum, heart and lung, on the other hand, were unaltered during development. The ontogeny-related changes in the enzyme were dissimilar to those for cAMP- and cGMP-dependent protein kinases previously reported, suggesting separate functional roles for the newly recognized Ca2+-target enzyme.