Photonics meets connectomics: case of diffuse, long-range horizontal projections in rat cortex
Photonics meets connectomics: case of diffuse, long-range horizontal projections in rat cortex
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DOI：
10.1117/1.nph.2.4.041403
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发表时间：
2015-10-01
期刊：
影响因子：
5.3
通讯作者：
Frostig, Ron D.
中科院分区：
文献类型：
--
作者：
Johnson, Brett A.;Frostig, Ron D.
近年来，在描述啮齿动物大脑不同区域之间的连接以建立“连接体”方面取得了进展。“这项工作涉及系统地收集新数据，以及在新的和预先存在的数据中描述网络关系的工具。为了生成这些连接体，在数据收集、分析和显示期间所做的选择强调了使用先验分组方案定义的皮质区域之间的密集的、特定的连接，该方案可能模糊数据中的某些空间关系。在这些连接体中不明显的连接模式的一个例子是弥漫性辐射，显然是非特异性的，跨越边界的，长距离水平轴突投射，这与大鼠皮层中诱发活动的水平传播有关。在这里，我们描述了水平投影系统，并探讨证据，这种投影内的连接体数据。我们认为，在光学和组织学方法和分析用于连接体的研究和我们自己的研究的差异如何导致不同的重点关于这个重要的水平投影模式。(C)2015年，美国光电仪器工程师学会（SPIE）
Recent years have seen progress in characterizing connections between different regions of the rodent brain to establish a "connectome." This effort involves systematically collected new data together with tools to characterize network relationships in new and preexisting data. The choices made during data collection, analysis, and display in order to generate these connectomes have emphasized dense, specific connections between cortical regions defined using a priori parcellation schemes that may obscure certain spatial relationships in the data. One example of a pattern of connectivity not clearly evident in these connectomes is a diffusely radiating, apparently nonspecific, border-crossing, long-range horizontal axonal projection that is related to horizontal spreads of evoked activity in the rat cortex. Here, we describe the horizontal projection system and explore evidence for this projection within the connectome data. We consider how the differences in optical and histological methodologies and analyses used for the connectome studies and our own studies lead to different emphases concerning this important horizontal projection pattern. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)