Changes in the Proportion of Inhibitory Interneuron Types from Sensory to Executive Areas of the Primate Neocortex: Implications for the Origins of Working Memory Representations.
Changes in the Proportion of Inhibitory Interneuron Types from Sensory to Executive Areas of the Primate Neocortex: Implications for the Origins of Working Memory Representations.
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DOI：
10.1093/cercor/bhaa056
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发表时间：
2020-03
期刊：
影响因子：
3.7
通讯作者：
Santiago Torres-Gomez;Jackson D. Blonde;Diego Mendoza-Halliday;Eric S. Kuebler;M. Everest;Xiao Jing Wang;W. Inoue;M. Poulter;J. Martinez-Trujillo
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文献类型：
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作者：
Santiago Torres-Gomez;Jackson D. Blonde;Diego Mendoza-Halliday;Eric S. Kuebler;M. Everest;Xiao Jing Wang;W. Inoue;M. Poulter;J. Martinez-Trujillo
编码工作记忆（WM）的神经元尖峰活动在灵长类关联皮层中很强，但在早期感觉皮层中较弱或不存在。这可能与跨区域神经元类型比例的变化有关，影响电路产生反复兴奋的能力。我们记录了执行 WM 任务的猴子的中颞叶 (MT)、内侧上颞叶 (MST) 和外侧前额皮质 (LPFC) 区域的神经元活动，并将神经元分为窄峰 (NS) 和宽峰峰 (BS)。 NS/BS 比值从 MT > MST > LPFC 降低。我们分析了艾伦研究所离体小鼠/人类细胞内记录的数据库来解释我们的数据。我们的分析表明，NS 神经元对应于小清蛋白 (PV) 或生长抑素 (SST) 中间神经元，而 BS 神经元对应于锥体 (P) 细胞或血管活性肠肽 (VIP) 中间神经元。我们对MT/MST和LPFC的猴组织切片中的神经元进行标记，发现皮质层2/3中PV的比例下降，而CR细胞的比例从MT/MST到LPFC增加。假设灵长类动物 CR/CB/PV 细胞与小鼠 VIP/SST/PV 细胞执行类似的计算，我们的结果表明，2/3 层细胞中 CR 和 PV 神经元比例的变化可能有利于关联区域中编码 WM 的活动的出现。
Neuronal spiking activity encoding working memory (WM) is robust in primate association cortices but weak or absent in early sensory cortices. This may be linked to changes in the proportion of neuronal types across areas that influence circuits' ability to generate recurrent excitation. We recorded neuronal activity from areas middle temporal (MT), medial superior temporal (MST), and the lateral prefrontal cortex (LPFC) of monkeys performing a WM task and classified neurons as narrow (NS) and broad spiking (BS). The ratio NS/BS decreased from MT > MST > LPFC. We analyzed the Allen Institute database of ex vivo mice/human intracellular recordings to interpret our data. Our analysis suggests that NS neurons correspond to parvalbumin (PV) or somatostatin (SST) interneurons while BS neurons are pyramidal (P) cells or vasoactive intestinal peptide (VIP) interneurons. We labeled neurons in monkey tissue sections of MT/MST and LPFC and found that the proportion of PV in cortical layers 2/3 decreased, while the proportion of CR cells increased from MT/MST to LPFC. Assuming that primate CR/CB/PV cells perform similar computations as mice VIP/SST/PV cells, our results suggest that changes in the proportion of CR and PV neurons in layers 2/3 cells may favor the emergence of activity encoding WM in association areas.