Using a combination of fMRI and anterior temporal lobe rTMS to measure intrinsic and induced activation changes across the semantic cognition network.
Using a combination of fMRI and anterior temporal lobe rTMS to measure intrinsic and induced activation changes across the semantic cognition network.
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DOI：
10.1016/j.neuropsychologia.2014.11.009
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发表时间：
2015-09
期刊：
影响因子：
2.6
通讯作者：
Ralph MA
中科院分区：
文献类型：
--
作者：
Binney RJ;Ralph MA
通过开发和应用一种结合fMRI和rTMS的方法来探索语义认知，我们确定了核心功能耦合网络元素的内在（与任务/刺激相关处理的自动变化有关）和诱导（即与TMS的影响有关）激活变化。低频rTMS应用于人类前颞叶（ATL）诱导：(a)刺激部位的局部抑制；(b)其他三个同侧语义区域的远程抑制；(c)对侧ATL的补偿性上调。随着时间的推移，对活动的进一步检查表明，代偿性变化似乎是对未受干扰网络内发生的内在变化的调制。除了提供对核心区域之间动态协作的见解外，观察体内内在和诱导变化的能力可能为了解神经系统患者群体功能恢复的关键机制提供重要机会。首次使用功能磁共振成像和rTMS联合研究语义认知。本征自动和经颅磁刺激诱导的激活变化。rTMS诱导对侧ATL的局部抑制和上调。代偿性变化与未扰动网络的内在变化有关。这些关键机制可能是神经系统患者功能恢复的基础。
By developing and applying a method which combines fMRI and rTMS to explore semantic cognition, we identified both intrinsic (related to automatic changes in task/stimulus-related processing) and induced (i.e., associated with the effect of TMS) activation changes in the core, functionally-coupled network elements. Low-frequency rTMS applied to the human anterior temporal lobe (ATL) induced: (a) a local suppression at the site of stimulation; (b) remote suppression in three other ipsilateral semantic regions; and (c) a compensatory up-regulation in the contralateral ATL. Further examination of activity over time revealed that the compensatory changes appear to be a modulation of intrinsic variations that occur within the unperturbed network. As well as providing insights into the dynamic collaboration between core regions, the ability to observe intrinsic and induced changes in vivo may provide an important opportunity to understand the key mechanisms that underpin recovery of function in neurological patient groups. First use of combined fMRI and rTMS to explore semantic cognition. Intrinsic-automatic and TMS-induced activation changes were identified. rTMS induced local suppression and up-regulation in the contralateral ATL. Compensatory changes relate to intrinsic variations in the unperturbed network. These key mechanisms may underpin recovery of function in neurological patients.