Mitochondrial transfer between cells can rescue aerobic respiration
Mitochondrial transfer between cells can rescue aerobic respiration
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DOI：
10.1073/pnas.0510511103
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发表时间：
2006-01-31
影响因子：
11.1
通讯作者：
Prockop, DJ
中科院分区：
文献类型：
--
作者：
Spees, JL;Olson, SD;Prockop, DJ
目前的理论表明，线粒体是在15亿年前从一种古老的原核生物中获得的。线粒体提供了有氧呼吸的能力，真核细胞的创造，最终复杂的多细胞生物。最近的报道发现，线粒体在衰老和决定寿命方面发挥着重要作用。多种遗传性和获得性疾病与线粒体功能障碍有关。我们在这里报告说，线粒体比以前认为的更具活力：线粒体或mtDNA可以在细胞之间移动。成体干细胞和体细胞的主动转移可以挽救具有无功能线粒体的哺乳动物细胞的有氧呼吸。
Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential roles in aging and determining lifespan. A variety of heritable and acquired diseases are linked to mitochondrial dysfunction. We report here that mitochondria are more dynamic than previously considered: mitochondria or mtDNA can move between cells. The active transfer from adult stem cells and somatic cells can rescue aerobic respiration in mammalian cells with nonfunctional mitochondria.