Terahertz tomographic imaging of freshly excised human breast tissues
Terahertz tomographic imaging of freshly excised human breast tissues
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DOI：
10.1117/1.jmi.6.2.023501
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发表时间：
2019-04-01
影响因子：
2.4
通讯作者：
El-Shenawee, Magda
中科院分区：
文献类型：
--
作者：
Bowman, Tyler;Vohra, Nagma;El-Shenawee, Magda
新鲜切除的乳腺癌肿瘤的太赫兹成像和光谱特征在 0.15 至 3.5 THz 范围内呈现。癌性乳腺组织是通过部分或全部切除恶性肿瘤获得的，而健康乳腺组织是通过乳房缩小手术获得的。对组织每个像素的实验数据进行反射光谱以获得折射率和吸收系数，形成断层扫描图像。折射率和吸收系数的透射光谱是从几个组织点的实验数据中检索的。比较透射模式和反射模式下癌症、脂肪和胶原组织区域的平均折射率和吸收系数。反射模式的优点是可以检索大量点的电特性，而无需像透射模式那样对刚切除的组织进行切片或更改。太赫兹光谱功率图像和断层扫描图像与病理学进行了良好的定性比较。 (C) 2019 年光电仪器工程师协会 (SPIE)
Terahertz imaging and spectroscopy characterization of freshly excised breast cancer tumors are presented in the range 0.15 to 3.5 THz. Cancerous breast tissues were obtained from partial or full removal of malignant tumors while healthy breast tissues were obtained from breast reduction surgeries. The reflection spectroscopy to obtain the refractive index and absorption coefficient is performed on experimental data at each pixel of the tissue, forming tomographic images. The transmission spectroscopy of the refractive index and absorption coefficient are retrieved from experimental data at few tissue points. The average refractive index and absorption coefficients for cancer, fat, and collagen tissue regions are compared between transmission and reflection modes. The reflection mode offers the advantage of retrieving the electrical properties across a significantly greater number of points without the need for sectioning or altering the freshly excised tissue as in the transmission mode. The terahertz spectral power images and the tomographic images demonstrated good qualitative comparison with pathology. (C) 2019 Society of Photo-Optical Instrumentation Engineers (SPIE)