BISTRAMIDE-A, BISTRAMIDE-B, BISTRAMIDE-C, BISTRAMIE-D, AND BISTRAMIDE-K - A NEW CLASS OF BIOACTIVE CYCLIC POLYETHERS FROM LISSOCLINUM-BISTRATUM
BISTRAMIDE-A, BISTRAMIDE-B, BISTRAMIDE-C, BISTRAMIE-D, AND BISTRAMIDE-K - A NEW CLASS OF BIOACTIVE CYCLIC POLYETHERS FROM LISSOCLINUM-BISTRATUM
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DOI：
10.1021/np50112a002
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发表时间：
1994-10-01
影响因子：
5.1
通讯作者：
DEBITUS, C
中科院分区：
文献类型：
--
作者：
BIARD, JF;ROUSSAKIS, C;DEBITUS, C
描述了四种新的环状聚醚的分离和表征，双酰胺B [2]，C [3]，D [4]和K [5]，它们与先前报道的来自新喀里多尼亚urochordata Lissoclinum bistratum的双酰胺A [1]密切相关。这些代谢产物的结构由光谱方法确定。这四种化合物对六种肿瘤细胞系表现出体外细胞毒性，包括人非小细胞肺癌（NSCLC-N6）细胞系。用bistramide K进行的细胞荧光分析显示NSCLC-N6细胞完全阻滞在G（1）期。双甲酰胺D和特别是双甲酰胺K比双甲酰胺A、B和C毒性小，因此在体内对NSCLC-NG有效。
The isolation and characterization is described of four novel cyclic polyethers, bistramides B [2], C [3], D [4], and K [5], which are closely related to the previously reported bistramide A [1] from the New Caledonian urochordata Lissoclinum bistratum. The structures of these metabolites were defined by spectroscopic methods. The four compounds exhibited in vitro cytotoxicity toward six tumor cell lines, including the human non-small cell lung carcinoma (NSCLC-N6) line. Cytofluorimetric analysis with bistramide K showed a complete block of NSCLC-N6 cells in the G(1) phase. Bistramide D and particularly bistramide K are less toxic than bistramides A, B, and C and are thereby effective in vivo against NSCLC-NG.