Young's Modulus of Canine Vocal Fold Cover Layers
Young's Modulus of Canine Vocal Fold Cover Layers
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DOI：
10.1016/j.jvoice.2013.12.003
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发表时间：
2014-07-01
期刊：
影响因子：
2.2
通讯作者：
Rafizadeh, Sassan
中科院分区：
文献类型：
--
作者：
Chhetri, Dinesh K.;Rafizadeh, Sassan
目标。本研究的目的是测量犬声带复盖层的弹性模数(杨氏模数)。基础科学研究。方法。解剖8只犬喉的声带复盖层。取自中膜、内侧声带表面区的覆盖层样本用于使用先前验证的压痕方法来测量材料硬度。来自两个人类喉部的覆盖层也被测量作为对照参考。分别测量上、下内侧覆盖层。共检测了15个犬骨上内侧表面和17个下内侧表面标本，以及2个和4个人体标本。犬喉内侧上表面的平均杨氏模数为4.2kPa(3.0~5.4kPa；标准差为0.6kPa)，下内侧表面的杨氏模数为6.8kPA(5.4~8.5kPA；SD为0.8kPA)。在人体覆盖标本上的内侧上表面和下内侧表面的测量结果分别为5.0kPa(范围4.7-5.4kPa；SD，0.5kPa)和7.0kPa(范围，6.7-7.3kPa；SD，0.3kPa)。人体测量结果与之前确认的测量结果相似。人和犬覆盖层标本的硬度测量结果无差异(P>；0.05)。犬和人声带复盖层的弹性刚度(杨氏模数)相似。研究结果支持使用犬喉作为研究发声的外部有效模型。
Objectives. The objective of this study was to measure the elastic modulus (Young's modulus) of canine vocal fold cover layers.Study Design. Basic science study.Methods. Cover layers from vocal folds of eight canine larynges were dissected. Cover layer samples from the mid-membranous, medial vocal fold surface area were used to measure material stiffness using a previously validated indentation method. Cover layers from two human larynges were also measured as control references. Superior and inferior medial cover layers were measured separately. A total of 15 superior medial surface and 17 inferior medial surface specimens from the canine and two and four specimens, respectively, from the human were tested.Results. In the canine larynges, the mean Young's modulus of the superior medial surface was 4.2 kPa (range, 3.0-5.4 kPa; standard deviation [SD], 0.6 kPa) and of the inferior medial surface was 6.8 kPa (range, 5.4-8.5 kPa; SD, 0.8 kPa). Measurements on human cover samples were 5.0 kPa (range, 4.7-5.4 kPa; SD, 0.5 kPa) and 7.0 kPa (range, 6.7-7.3 kPa; SD, 0.3 kPa) for the superior medial and inferior medial surface, respectively. Human measurements were similar to the previously validated measurements. There was no difference between the stiffness measurements in the human and canine cover layer samples (P > 0.05).Conclusions. The elastic stiffness (Young's modulus) of the canine and human vocal fold cover layers is similar. Findings support the use of canine larynx as an externally valid model to study voice production.