Quality of life in Dutch women with lichen sclerosus
Quality of life in Dutch women with lichen sclerosus
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DOI：
10.1111/bjd.12137
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发表时间：
2013-04-01
影响因子：
10.3
通讯作者：
van der Meijden, W. I.
中科院分区：
文献类型：
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作者：
Lansdorp, C. A.;van den Hondel, K. E.;van der Meijden, W. I.
背景 硬化性苔藓（LS）是一种慢性炎症性皮肤病。早期研究表明健康相关生活质量 (HRQoL) 受损，但尚未报道更广泛的研究，包括通用问卷。 目的 通过横断面研究，调查患有 LS 的荷兰女性样本的 HRQoL；将得出的 HRQoL 数据与其他皮肤病和荷兰普通人群的数据进行比较；探讨可能影响 HRQoL 的因素。方法 荷兰 LS 基金会和支持小组的女性成员以电子方式填写了三份问卷：Skindex-29、SF-12 和 EQ-5D 视觉模拟量表 (VAS)。我们将 Skindex-29 分数分为对 HRQoL 影响“很小”（分数 0-24）、“轻度”（25-31）、“中度”（32-43）和“严重”（44-100）的组。我们使用 Mann-Whitney U 检验和 Kruskal-Wallis 检验比较差异，并使用 Spearman 等级相关系数比较相关性。结果 总共纳入了 262 名患有 LS 的女性。平均诊断延迟为 4.9 (SD 7.1) 年。患者的平均 Skindex-29 总得分为 38.4（0-100，SD 17.2）。症状、情绪和功能的领域得分分别为 46.8 (SD 19.0)、38.2 (SD 20.2) 和 33.6 (SD 19.3)。 SF-12 的平均 PCS-12（身体部分）和 MCS-12（精神部分）得分分别为 47.7 和 48.5。对于荷兰人口来说，这些分数分别为 49.3 和 52.3。平均 EQ-5D VAS 评分为 74.1 (SD 15.4)。结论 荷兰女性 LS 患者的诊断存在相当大的延迟。 Skindex-29 领域评分显示 HRQoL 中度受损。患有 LS 的女性报告的一般 HRQoL 低于荷兰女性平均水平。
Background Lichen sclerosus (LS) is a chronic inflammatory skin disease. Earlier studies have shown an impaired health-related quality of life (HRQoL), but more extensive research including generic questionnaires has not been reported.Objectives To investigate, in a cross-sectional study, the HRQoL of a sample of Dutch women with LS; to compare the resulting HRQoL data with that available from other skin diseases and the general Dutch population; to explore factors that may influence the HRQoL.Methods Female members of the Dutch LS Foundation and Support Group filled out three questionnaires electronically: the Skindex-29, the SF-12 and the EQ-5D visual analogue scale (VAS). We distinguished Skindex-29 scores into groups with 'little' (score 0-24), 'mild' (25-31), 'moderate' (32-43) and 'severe' (44-100) impact on HRQoL. We compared differences using the Mann-Whitney U-test and the Kruskal-Wallis test, and correlations using Spearman's rank correlation coefficient.Results A total of 262 women with LS were included. The average diagnostic delay was 4.9 (SD 7.1) years. Patients had a mean total Skindex-29 score of 38.4 (0-100, SD 17.2). Domain scores for symptoms, emotions and functioning were 46.8 (SD 19.0), 38.2 (SD 20.2) and 33.6 (SD 19.3), respectively. The SF-12 showed average PCS-12 (physical component) and MCS-12 (mental component) scores of 47.7 and 48.5, respectively. For the Dutch population these scores were 49.3 and 52.3. The mean EQ-5D VAS score was 74.1 (SD 15.4).Conclusions There is a considerable delay in diagnosis for female Dutch patients with LS. The Skindex-29 domain scores showed a moderately impaired HRQoL. Women with LS reported a lower generic HRQoL than the average female Dutch population.