T7 Phage Display Library a Promising Strategy to Detect Tuberculosis Specific Biomarkers.
T7 Phage Display Library a Promising Strategy to Detect Tuberculosis Specific Biomarkers.
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DOI：
10.4172/2161-1068.1000214
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
H. Talwar;J. Talreja;L. Samavati
中科院分区：
文献类型：
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作者：
H. Talwar;J. Talreja;L. Samavati
世界上三分之一的人口感染了结核病，只有 10% 的人会发展为活动性疾病，其余 90% 的人被认为患有潜伏性结核病 (LTB)。虽然活动性结核病具有传染性并且可能致命，但长期结核病可以演变为活动性结核病。由于表现和非特异性体征和症状的多样性，结核病的诊断可能具有挑战性，尤其是在早期阶段。目前，我们可用于诊断活动性结核病、预测活动性结核病的治疗效果和治愈、潜伏性结核病感染的重新激活以及通过疫苗接种诱导保护性免疫反应的工具有限。因此，鉴定稳健且准确的结核病特异性生物标志物对于成功根除结核病至关重要。在这篇评论中，我们总结了诊断和区分活动性结核病和LTB的可用方法及其局限性。此外，我们提出了一种新型肽微阵列平台作为识别结核病生物标志物的有前景的策略。
One-third of the world's population is infected with tuberculosis, only 10% will develop active disease and the remaining 90% is considered to have latent TB (LTB). While active TB is contagious and can be lethal, the LTB can evolve to active TB. The diagnosis of TB can be challenging, especially in the early stages, due to the variability in presentation and nonspecific signs and symptoms. Currently, we have limited tools available to diagnose active TB, predict treatment efficacy and cure of active tuberculosis, the reactivation of latent tuberculosis infection, and the induction of protective immune responses through vaccination. Therefore, the identification of robust and accurate tuberculosis-specific biomarkers is crucial for the successful eradication of TB. In this commentary, we summarized the available methods for diagnosis and differentiation of active TB from LTB and their limitations. Additionally, we present a novel peptide microarray platform as promising strategy to identify TB biomarkers.